Medicine
Permanent URI for this communityhttp://repository.kln.ac.lk/handle/123456789/12
This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
Browse
4 results
Search Results
Item Design and development of a web based histopathology reporting system(Sri Lanka Medical Association, 2017) Ediriweera, D.S.; Hettiarachchi, W.G.; Mahendra, B.A.G.G.; Liyanage, S.K.; Ratnayake, R.M.U.S.; Hewavisenthi, S.J.de.S.INTRODUCTION & OBJECTIVES: The current histopathology reporting system in the unit has only basic features including report generation and limited data retrieval. Thus a newer system was required to address the issues faced in histopathology reporting, chiefly a prolonged turnaround time caused by lack of clinical data, inability to track delays in sample processing, delays in data entry and report dispatch. More efficient data retrieval for research purposes and monitoring of postgraduate training were also considered important. The aim of the study was to design and develop a generic histopathology reporting system that facilitates the generation of timely reports and helps in research and postgraduate training. METHODS: A software framework was designed and developed into a functional web based histopathology reporting system (WBHPRS) which can be easily customizable to different settings. This was designed using MySQL and PHP. Data entry was facilitated by using drop down menus and prompts. Standard templates for reports with the option to edit were uploaded enabling quick report generation. RESULTS: A WBHPRS has the ability to capture data throughout the process of generating a report, thus enabling the tracking of the specimen from surgery to dispatch of the report. The system also provides facilities for more efficient data retrieval due to a modified coding system. It facilitates postgraduate supervision enabling the trainer to determine the time taken, quality and quantity of work done by the trainees. CONCLUSION: This system has vastly enhanced features that will improve the timeliness of reporting and provide additional features useful in research and postgraduate training.Item A Retrospective study on perinatal post-mortems(University of Kelaniya, Sri Lanka, 2016) Liyanage, S.K.; Mahendra, B.A.G.G.; Ratnayake, R.M.U.S.; Hewavisenthi, S.J.A post-mortem examination is the key to the recognition of pathologies related to perinatal deaths. A perinatal death could be related to fetal, maternal or placental factors. A complete perinatal post-mortem (PPM) includes examination of the dead body and the placenta. The PPM findings assist the clinical team in confirming their clinical findings and uncover the additional pathologies, and the family for future pregnancy planning. This study was carried out to identify the number of perinatal post mortems (PPMs) reported during the study period, the number of PPMs with multiple congenital anomalies and the number of PPMs accompanied by a placenta and the number of placentae with identifiable pathology. This study was on already reported PPMs in a tertiary care center from January 2011- August 2016. Multiple congenital anomalies were noted in 14% (16/118) of the PPMs. Placentae were submitted for examination in 26% (31/118) with clinically significant placental pathologies in 23% (7/31). In 64% (76/118) of PPMs there were no gross abnormality in the fetus/baby. The placenta was not available for examination in 72% (55/76) and therefore, the possibility of placental pathology, which might have led to the death, could not be excluded.Item Lymphoid tangles is a useful cytological feature in the diagnosis of Hashimoto thyroiditis(Sri Lanka Medical Association, 2007) Ratnayake, R.M.U.S.; Hewavisenthi, S.J.de S.INTRODUCTION: A cytological diagnosis of Hashimoto thyroiditis (HT) is made in the presence of Hurthle cells in a background of plasma cells and lymphocytes. The presence of lymphoid tangles as a diagnostic feature has been described only in isolated case reports. OBJECTIVE: To assess the value of lymphoid tangles in the cytological diagnosis of HT. DESIGN, SETTING AND METHODS: Forty one smears with an unequivocal cytological diagnosis of HT and 41 smears of colloid storing goitres (CSG) were selected. 10 high power fields of the most cellular smear were assessed for lymphoid tangles defined as haemotoxyline stained fibrillary material. The presence of lymphoid tangles were graded as Grade 0 - absence of tangles/10 hpf; Grade 1 - presence of tangles in <50% /lOhpf and Grade 2 - presence of tangles in >50% /lOhpf. The observer had no knowledge of the initial diagnosis. The likelihood ratio was calculated; those above 10 and below 0.1 considered as strong evidence for the presence or absence of disease respectively. RESULTS: In the 41 CSG smears, 33 (80.4%) showed no tangles and 8 (19.5%) showed grade 3 tangles. None of the smears showed grade 2 tangles. All 41 cases of HT revealed lymphoid tangles with 34 (82.9%) having grade 2 tangles and 7 (17%) grade 1 tangles. The likelihood ratio was 0.00, 0.85 and 34.0 respectively for Grade 0, Grade 1 and Grade 2 tangles. Grade2 lymphoid tangles were strongly predictive of a diagnosi s of HT. CONCLUSION: The presence of Grade 2 lymphoid tangles in the smears is a useful diagnostic feature in HT.Item Histological study of macroscopically normal mucosa adjacent to tumour in colorectal resection specimens(College of Pathologists of Sri Lanka, 2012) Ratnayake, R.M.U.S.; Hewavisenthi, S.J.de S.OBJECTIVE: To study the histological features of macroscopically normal mucosa in colorectal carcinoma specimens and attempt to correlate the severity of these changes and the distance of the mucosa from the tumour. METHOD: Ninety three resection margins from 52 specimens were categorized according to the distance from the tumour, 0-1cm, 1.1-5cm and more than 5cm. The histological parameters assessed included, lymphoid aggregates, acute inflammation, chronic inflammation, crypt distortion and villous change. These were graded as absent, mild, moderate and severe. The presence of intraepithelial lymphocytes, cystically dilated ducts and epithelial erosions were recorded as absent or present. Results were analyzed using Pearson Chi- square test and Fischer-Exact statistics. .RESULTS: The histological features found included, lymphoid aggregates in 40% acute inflammation in 15% chronic inflammation in 16% crypt distortion 17%, cystically dilated glands 21%, epithelial erosion 13% and villous change 32%. The presence of cystically dilated glands showed a significant correlation with the distance from the tumour. CONCLUSION: Varied histopathological features were observed in the mucosa adjacent to the tumour, awareness of which can prevent misinterpretation and over diagnosis of these features.