Books and Chapters of Books
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Item Side effects of drugs annual(Elsevier, 2001) de Silva, H.J.This chapter presents an overview and discusses the effects of various antiemetics. These drugs include cisapride, clebopride, domperidone, and 5-HT3 receptor antagonists. Clebopride can cause extrapyramidal syndromes, ranging from transient dyskinesia to persistent parkinsonism and tardive dykinesia. The efficacy and adverse effects of domperidone and metoclopramide have been compared in a double-blind, multicenter, randomized trial in 93 insulin-dependent diabetics with symptomatic gastroparesis. The safety and efficacy of the selective 5-HT3 receptor antagonist alosetron in the treatment of irritable bowel syndrome is reviewed. In patients with irritable bowel syndrome, alosetron increases colonic transit time and colonic compliance. Constipation is the most common adverse effect. Several histamine H2 receptor antagonists, such as like cimetidine, and ranitidine are discussed. The drug interactions associated with cimetidine are explained. Cimetidine can interact with other drugs by inhibiting hepatic cytochrome P450.Item Side effects of drugs annual(Elsevier, 2000) de Silva, H.J.This chapter provides an overview of gastrointestinal drugs. Some of the drug classes discussed include antacids, antiemetics, ulcer healing drugs, and cholelitholytic agents—bile acids. The chapter describes the clinical use of cisapride and its risk:benefit ratio in children. The most common adverse effects are diarrhea, abdominal cramps, borborygmi, and colic. Serious adverse events are rare and include isolated cases of extrapyramidal reactions, seizures in epileptic patients, cholestasis, and ventricular dysrhythmias, anorexia, and enuresis. Coadministration of anticholinergic drugs may compromise the beneficial effects of cisapride. Several treatments are available for promoting the healing of gastric and duodenal ulcers associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs). They include histamine receptor antagonists, proton pump inhibitors, and prostaglandin analogues. Proton pump inhibitors can interact with other drugs by increasing gastric pH, inhibiting hepatic cytochrome P450, or inducing specific isoforms of this enzyme system. However, drug interactions involving these isoenzymes and omeprazole or lansoprazole are uncommon and generally appear to be clinically unimportant.Item A Methodical approach to medical terminology(Authour, 2009) Salgado, S.; Athukorala, U. V.No abstract availableItem Handbook on general laboratory procedures, safety considerations and housekeeping in a DNA laboratory environment(Authour, 2009) Manamperi, A.No abstract availableItem DNA profiling technology in identity testing and their applications(Authour, 2009) Manamperi, A.No abstract availableItem Genome, gene expression and regulation in Prokaryotes(Author, 2009) Gunawardene, Y.I.N.S.No abstract availableItem Methyl Farnesoate in Crustacean Endocrine control(Author, 2009) Gunawardene, Y.I.N.S.No abstract availableItem Item Bioinformatics and DNA micro-arrays in post genomic analysis(Author, 2009) Dassanayake, R.S.; Gunawardene, Y.I.N.S.No abstract availableItem Neurovascular bundle of upper limb for medical undergraduates(Salgado, S., 2009) Salgado, S.; Abeysuriya, V.No abstract available