Books and Chapters of Books
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Item 14 Topics in health professions education: A guide to practical wisdom.(College of Medical Educations., 2020) Chandratilake, M.; Olupeliyawa, A.Item A 16-year-old boy from Sri Lanka with fever, jaundice and renal failure: Leptospirosis(Saunders Ltd, 2014) Premaratna, R.No abstract availableItem A 45-year-old man from Sri Lanka with fever and right hypochondrial pain: amoebic liver abscess(Saunders Ltd, 2014) Premaratna, R.No abstract avaialbleItem A 58-year-old woman from Sri Lanka with fever, deafness and confusion: scrub typhus(Saunders Ltd, 2014) Premaratna, R.No abstract availableItem Abnormal labour(Taylor and Francis Group, 2021) Padumadasa, S.; Goonewardene, M.No abstract availableItem Acute fatty liver of pregnancy(Taylor and Francis Group, 2021) de Silva, J.; Padumadasa, S.No abstract availableItem Acute uterine inversion(Taylor and Francis Group, 2021) Padumadasa, S.; Gunawardana, K.No abstract availableItem Adolescent sexual practices and contraceptive usage(Faculty of Medicine, University of Kelaniya & Plan International, 2008) Herath, H.M.R.P.; Dissanayake, D.M.A.B.; Hilmi, M.A.M.; Pathmeswaran, A.; Wijesinghe, P.S.INTRODUCTION: Adolescence is a critical period of development, as adoption of unhealthy risk behaviours such as unprotected sex, smoking and drug abuse, avoiding contraceptive methods will lead to long standing health and socioeconomic consequences. Therefore information is needed about the sexual practices and contraceptive usage of adolescents and young adults to develop interventions in the community. This study was undertaken to describe and compare the sexual practices, knowledge and usage of contraceptives by adolescents and young adults in selected urban and rural settings.METHOD: This cross sectional descriptive study was conducted among young adults aged less than 21 years at the time of interview in three settings in both rural and urban areas. The study subjects were students from universities, technical colleges and garment factory workers representing both rural and urban areas. The data was collected using a pretested self administered questionnaire during June 2007 to August 2007. Information collected included marital status, gender and the level of education, first sexual relationship (age, partner, contraception used), current contraceptive practices and knowledge about contraceptive methods. The data was analysed using SPSS 10.1 statistical package. Informed consent was obtained from all participants. RESULTS : There were a total of 1258 subjects who had returned the completed questionnaires. Out of them there were 290 garment factory employees, 480 technical college students, and 488 university students. The percentage of females was 58.9%. The mean ages of the males and the females of the total population were 20.75(50 1.13) years and 20.55(SD 1.63) and it was similar in the three settings. The level of education was highest among the undergraduates lowest among garment factory workers. Out of the population 303 (24.1%) were sexually active. It was significantly higher among males {33.5%0 than females (17.0%). Both among male and females this trend was significantly more common among garment factory workers. Sexual activity of the unmarried and the premarital sexual practices of married subjects are shown in the table. 6. 17% of females and 33.5% of males were sexually active before marriage. 90% male garment factory workers were sexually active. In contrast the proportionItem Advances in Aedes mosquito vector control strategies using CRISPR/Cas9(Springer, 2021) Wickramasinghe, P.D.S.U.; Silva, G.N.; Gunawardene, Y.I.N.S.; Dassanayake, R.S.Advancements in genetic engineering have resulted in the development of mosquitoes with impaired vector competence, thereby limiting acquisition and transmission of pathogens. The main dengue (DENV) vector, Aedes aegypti, is an invasive species that have spread unwittingly across the world as a result of human trade and travel. The Ae. aegypti mosquito species has spread across tropical and subtropical regions, with higher presence in urban regions where rapid breeding patterns have shown in artificial containers. Identification of and treating an adequate number of mosquito breeding sites as a control measure have been done for the past couple of years, and yet improvement is far from the expectations, even with well-funded and well-organized initiatives. In order to stop the pathogen transmission, genetically modified mosquitoes (GMM) needs to be created and released. Despite many Aedes-related achievements, GMM creation has been challenging. The spread of particular genetic elements that impair vector competence, trigger deleterious recessive mutations, or skew a population's sex ratio can be used to prevent the spread of vector disease, or eradicate invasive organisms in a species-specific and eco-friendly manner. In recent years, genome editing strategies have evolved to make use of a variety of nucleases, ranging from sequence-specific zinc finger nucleases to modular TALENs (transcription activator-like effector nucleases) and most recently, RNA-guided nucleases adapted from bacterial adaptive immune systems, dubbed CRISPR/Cas (clustered regularly interspaced palindromic repeats/CRISPR associated systems). By combining these methods, a new era in gene editing had emerged. Generally, both of these gene editing technologies utilize sequence-specific nucleases to generate double-stranded DNA breaks (or nicks) in the target sequence, resulting in desired DNA modifications using endogenous DNA repair mechanisms. Since cells with DNA lesions are unable to divide further, the nuclease-generated strand breaks must be rapidly repaired by the cell to maintain the viability. CRISPR/Cas has been widely accepted for use in a variety of organisms, including insect species, with only minor optimization steps needed thus far. CRISPR/Cas9 technology transformed the process of engineering nucleases capable of cleaving complex genomic sequences. A complementary guide RNA (gRNA) directs the Cas9 endonuclease's operation to the specific DNA target site, enabling the editing of virtually any DNA sequence without complex protein engineering and selection procedures. Apart from genome editing, the specificity and flexibility of the CRISPR/Cas9 method enables unprecedented rapid development of genetically modified organisms with mutation systems for disease vector insect control. The stability and expression of the gene construct generated by CRISPR/Cas9 or any other method must be addressed before GMM are released, in order to make sure that pathogen transmission and formulation are interrupted robustly and completely. Spreading foreign antipathogen genes through gene drive strategies among wild mosquito populations strengthens the case for a more streamlined approach. Major fields that must be adequately assessed include risk evaluation and management, conducting studies to ensure human and environmental protection, developing effective control strategies built on comprehensive gene-driving systems, and adequately addressing the ethical, legal, and social consequences of GMM release. Although GMM is theoretically feasible as a disease control method, field releases should be made only when strong scientific evidence of human and environmental protection and effectiveness are presented, and public acceptance is addressed appropriately. This chapter discusses the diverse technological advances in generating Ae. aegypti mosquitoes which are resistant to dengue virus (DENV) and other diseases, as well as the biosafety and risk assessment of these procedures. Additionally, the chapter outlines a convincing path forward for developing successful genetic-based DENV control strategies based on CRISPR/Cas9, which could be expanded to control other arboviruses while maintaining biosafety.Item Item Item Approaches to the multiple choice questions in histology(Authour, 2011) Salgado, S.No abstract availableItem Assisted vaginal breech delivery(Taylor and Francis Group, 2021) Padumadasa, S.; Goonewardene, M.No abstract availableItem Biochemistry for clinical medicine(Greenwich Medical Media, 2001) Thabrew, I.; Ayling, R. M.; Wicks, C.No abstract availableItem Bioinformatics and DNA micro-arrays in post genomic analysis(Author, 2009) Dassanayake, R.S.; Gunawardene, Y.I.N.S.No abstract availableItem Cardiac emergencies in obstetrics(Taylor and Francis Group, 2021) Padumadasa, S.; Rajapakse, S.No abstract availableItem Cardiology(Samudra Medical Publications, 2022) Weerasuriya, D.; Mettananda, S.No abstract availableItem Characteristics of menarche in adolescent girls in Sri Lanka(Faculty of Medicine, University of Kelaniya & Plan International, 2008) Salgado, L.S.S.; Abeysuriya, V.; Wickremasinghe, A.R.INTRODUCTION: Menarche is an important biological milestone in girls. The age at attainment of menarche is important for implementing programmes to improve the life skills of girls. OBJECTIVE: To describe the characteristics of menarche, the factors influencing the onset of menarche and to describe the knowledge, beliefs and practices during menarche of adolescent girls in Sri Lanka. Methods: This cross sectional study was conducted among girls 10-16 years of age in four schools situated in the Ragama Medical Officer of Health (MOH) area. Six hundred and sixty two girls were randomly selected and data were collected using a pre-tested, self-administered questionnaire. RESULTS: The median age of our sample was 13 years (range 10-16 years); the mean and median ages of attaining menarche were 12,53 and 11,48 years respectively. The mean BMI of girls who had attained menarche was 17.6 (SEM 0.22) Kg/m2 and those who did not was 16.92 (SEM 0.32) Kg/m2. 47% of the girls had a menstrual cycle length of e" 29 days, 23.4% had irregular cycles and 59% reported that the duration of bleeding was 3-5 days. First borns reported a IcJwer mean age at menarche (12.34 years) than the later borns (12.6 years) (p=0.02). Girls from single child families, who were from higher social categories (Categories 1 & 2) and whose parents were educated beyond 0/L attained menarche earlier. 40.8% stated that menstrual blood is not dirty, 70% admitted that there was no prohibition of having cold or sour foods. The majority of the students had adequate knowledge regarding physical changes during menarche. Girls experienced negative emotions during menstruation. CONCLUSION: The median age of attaining menarche is 11.48 years. Girls experienced negative emotions during menstruation.Item Item Clinical evaluation of children with constipation: history and physical examination(Nova Science Publishers Inc, 2013) Rajindrajith, S.; Devanarayana, N.M.; Benninga, M.A.