Books and Chapters of Books
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Item Gastroenterology Update(Gastroenterological and Digestive Endoscopy Society Sri Lanka Colombo, Sri Lanka, 1993) Goonaratna, C.; de Silva, H.J.No abstract availableItem Side effects of drugs annual(Elsevier, 1999) de Silva, H.J.This chapter describes the adverse effects of gastrointestinal drugs. The adverse effects of cisapride include abdominal cramps, diarrhea, headache, dystonic reactions, convulsions, and hypersensitivity. Cisapride cardiotoxicity in association with erythromycin is described in the chapter. Cisapride should be used with caution in patients with severe cardiac disease or other risk factors for developing dysrhythmias, particularly hypokalemia and hypomagnesemia. It should not be given to patients with intestinal obstruction, perforation, or hemorrhage. In adults, metoclopramide has been reported to cause gynecomastia and galactorrhea due to hyperprolactinemia secondary to its dopamine antagonist action. Adverse effects attributable to antiemetic therapy include facial rash, constipation, headache, and weakness. The increased risk of acute liver injury with cimetidine is seen mainly in the first two months of use. In a study discussed in the chapter, gynecomastia and a lobular carcinoma of the breast were reported in a patient with chronic gastric ulcer. The hematological adverse effects of ranitidine include leukopenia, thrombocytopenia, aplastic anemia, hemolytic anemia, and pancytopenia.Item Intestinal nematodes that migrate through lungs (Ascariasis)(WB Saunders Company, 2000) de Silva, N.R.; Bundy, D.A.P.Item Side effects of drugs annual(Elsevier, 2000) de Silva, H.J.This chapter provides an overview of gastrointestinal drugs. Some of the drug classes discussed include antacids, antiemetics, ulcer healing drugs, and cholelitholytic agents—bile acids. The chapter describes the clinical use of cisapride and its risk:benefit ratio in children. The most common adverse effects are diarrhea, abdominal cramps, borborygmi, and colic. Serious adverse events are rare and include isolated cases of extrapyramidal reactions, seizures in epileptic patients, cholestasis, and ventricular dysrhythmias, anorexia, and enuresis. Coadministration of anticholinergic drugs may compromise the beneficial effects of cisapride. Several treatments are available for promoting the healing of gastric and duodenal ulcers associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs). They include histamine receptor antagonists, proton pump inhibitors, and prostaglandin analogues. Proton pump inhibitors can interact with other drugs by increasing gastric pH, inhibiting hepatic cytochrome P450, or inducing specific isoforms of this enzyme system. However, drug interactions involving these isoenzymes and omeprazole or lansoprazole are uncommon and generally appear to be clinically unimportant.Item Side effects of drugs annual(Elsevier, 2001) de Silva, H.J.This chapter presents an overview and discusses the effects of various antiemetics. These drugs include cisapride, clebopride, domperidone, and 5-HT3 receptor antagonists. Clebopride can cause extrapyramidal syndromes, ranging from transient dyskinesia to persistent parkinsonism and tardive dykinesia. The efficacy and adverse effects of domperidone and metoclopramide have been compared in a double-blind, multicenter, randomized trial in 93 insulin-dependent diabetics with symptomatic gastroparesis. The safety and efficacy of the selective 5-HT3 receptor antagonist alosetron in the treatment of irritable bowel syndrome is reviewed. In patients with irritable bowel syndrome, alosetron increases colonic transit time and colonic compliance. Constipation is the most common adverse effect. Several histamine H2 receptor antagonists, such as like cimetidine, and ranitidine are discussed. The drug interactions associated with cimetidine are explained. Cimetidine can interact with other drugs by inhibiting hepatic cytochrome P450.Item Manual of basic cervical cytology(National Cancer Control Programme,Colombo, 2001) Kumarasinghe, P.; Hewavisenthi, J.No abstract availableItem Biochemistry for clinical medicine(Greenwich Medical Media, 2001) Thabrew, I.; Ayling, R. M.; Wicks, C.No abstract availableItem Control of intestinal helminthiasis in pregnancy – the Sri Lankan experience(World Health Organization, 2003) Ismail, M.M.; Atukorala, T.M.S.; Naotunna, T.S; de Silva, N.R.; Hettiarachchi, I.Item මානසික රෝග හදුනා ගනිමු(University of Kelaniya, 2004) Kuruppuarachchi, K.A.L.A.Item Psychiatry in Sri Lanka(Vikas Medical Publishers, Mumbai, 2005) Kuruppu, L.Item Soil-transmitted helminth infections in Sri Lanka(Federation of Asian Parasitologists, AAA Committee, 2005) de Silva, N.R.No abstract availableItem Helminth infections: soil-transmitted helminth infections and schistosomiasis(Oxford University Press and World Bank, 2006) Hotez, P. J.; Bundy, D.A.P.; Beegle, K.; Brooker, S.; Drake, L.; de Silva, N.; Montresor, A.; Engels, D.; Jukes, M.; Chitsulo, L.; Chow, J.; Laxminarayan, R.; Michaud, C. M.; Bethony, J.; Correa-Oliviera, R.; Xiao Shu-Hua; Fenwick, A.; Savioli, L.Item Collective violence(World Health Organization, 2008) Kitulwatte, I.D.G.; de Silva, S.T.G.R.; Siriwardhane, H.A.No abstract availableItem Fatal violence – Homicides(World Health Organization, 2008) Kitulwatte, I.D.G.; de Silva, S.T.G.R.No abstract availableItem Sri Lankan parents' attitudes towards adolescent reproductive and sexual health education needs: A qualitative study(Faculty of Medicine, University of Kelaniya & Plan International, 2008) Godamunne, P.K.S.INTRODUCTION: Adolescents have unique reproductive health needs when compared to adults, and the behaviours adopted in adolescence have serious implications for their later well being. Serious gaps have been found in providing sexual and reproductive health information to adolescents in Sri Lanka. OBJECTIVE: To explore the attitudes of Sri Lankan parents' towards adolescent reproductive and sexual health education, to identify current parental practices of imparting reproductive and sexual health information to their children and to identify perceived barriers parents face in discussing sexual and reproductive health issues with their children. METHODS: A qualitative study conducted using focus groups discussions in Kurunegala, Kandy, Gampaha and Colombo districts among 71 parents having an adolescent child. RESULTS: All'parents said that it was essential to provide reproductive and sexual health education to adolescents, mainly to deter them from engaging in any precocious sexual activity and to protect children from various threats posed by society, such as sexually transmitted diseases and child sexual abuse. Generally most parents were reluctant to directly discuss reproductive and sexual health issues with their children due to cultural taboos and resultant feelings of shyness and embarrassment. However, mothers, to some extent, discussed reproductive and sexual health matters with their children, often with their daughters and sometimes even with sons. However, some parents expressed lack of knowledge to do so. Parents also indirectly educated their children on sexual and reproductive health topics by providing them with books to read. Many parents considered school and teachers to be the best source of reproductive and sexual health information for their children. Doctors too were considered by parents to be a reliable source of reproductive and sexual health information. CONCLUSION: Parents considered adolescent reproductive and sexual health education as essential to protect and deter children from engaging in any precocious sexual activity. However, most parents were reluctant to openly discuss reproductive and sexual health topics with their children. In general, parents preferred outside sources, people other than themselves, such as teachers and doctors to provide their children with reproductive and sexual health information.Item Item An exploratory qualitative study on marriage and pregnancy of adolescent females in the Hikkaduwa Medical Officer of Health (MOH) area(Faculty of Medicine, University of Kelaniya & Plan International, 2008) Kasturiratne, K.T.A.A.INTRODUCTION: Marriage in adolescence before 18 years is prohibited in Sri Lanka. However, marriages of adolescent females are not rare in some areas in Sri Lanka. OBJECTIVE: To describe the factors associated with marriage of and pregnancy among adolescent females (14-17 years) in a village in the Hikkaduwa Medical Officer of Health (MOH) area. METHODS: This exploratory qualitative study was conducted in Angankanda in the Kalupe PHM division in the Hikkaduwa MOH area in November 2007. Data were collected through focus group discussions and key informant interviews and analysed using qualitative content analysis. RESULTS: Fourteen females who had been married during adolescence (14-17 years) and five key informants participated in the study. Marriages of adolescent females have taken place following emotional relationships. Married adolescents have a low level of education and reduced awareness about health issues. Death or separation of a parent, poverty and lack of security within the family unit are important predisposing factors to adolescent marriages. Elopement is common following which parents or relatives from both parties collaborate to register the marriage to avoid litigation on the male partner. Most male partners are above 18 years of age at the time of the marriage. The age of the adolescent provided at registration of the marriage was false. Public health field staff of the area were aware of the problem and have taken preliminary steps to focus on this group. The services provided by the Public Health Midwife for married females are sought and acknowledged but not strictly adhered to, due to negative pressures or lack of motivation from the family. Delaying of the first pregnancy is not a common practice. Exposure to other modes providing awareness on health issues is limited. CONCLUSION: Despite legislature, marriages of adolescent females are a common occurrence in this community. Targetted interventions to prevent these marriages and to upgrade the overall health of adolescent females are necessary in areas where this problem is prevalent.Item A comparative descriptive study on adolescents presented to Ragama and Anuradhapura Teaching Hospitals for medico-legal examination with a history of 'sexual activity'(Faculty of Medicine, University of Kelaniya & Plan International, 2008) Edirisinghe, P.A.S.; Perera, W.N.S.; Paranithran, P.; Perera, B.P.P.; Samarasekera, A.; Waidarathna, M.D.; Jayasena, A.S.INTRODUCTION: Adolescents engaged in sexual activity are brought for medico-legal examination as they are minors. Though some have consented for sexual activity, it is not legally acceptable. The perpetrators include boyfriends, relatives, known persons and strangers. The 'boyfriend' group is unique as the consent is not obtained by illegal means. OBJECTIVE: To find out potential predisposing factors that contribute to 'consensual' or 'non consensual' sexual activity of adolescents and to find out how 'consensual' and 'non consensual' sexual activity affects sexual health of adolescents. METHODS: A retrospective descriptive study was done using records maintained at the offices of the Judicial Medical Officers of Ragarna and Anuradhapura. The data was analyzed using SPSS statistical package. RESULTS: 202 and 154 victims examined between 2000 to 2006 at Ragama and Anuradhapura were analyzed. Male to female ratio was 1:10 in Ragama and 1:24 in Anuradhapura. The most vulnerable age group for sexual activity was 14-15 years. The majority of cases were from the low socio-economic strata. Vaginal intercourse was the most preferred sexual activity; the likelihood of an adolescent from Anuradhapura to have penetrative sex was 2.47 times more as compared to an adolescent from Ragama. Boyfriend was the assailant in 39% and 37% of cases in Ragama and Anuradhapura respectively. 63 % of victims from Ragama had eloped as compared to 19% from Anuradhapura. In both groups, nearly half of the cases had a relationship less than 6 months. An adolescent having sexual activity with a relative was 2.31 (95% CI 1.36-3.93) times greater in Anuradhapura as compared to Ragama. There were 18 and 16 pregnancies in Ragama and in Anuradapura, respectivly. 61 cases from Ragama had psychological symptoms and signs after the incident. CONCLUSIONS: Adolescents are more susceptible to engage in sexual acts around 14 years. Consented sexual activity with a boy friend resulting in legal action is a significant social problem. The high incidence of sexual activity with relatives and known persons indicate the vulnerability of adolescents to engage in sexual activity in their own environments.Item Adolescent sexual practices and contraceptive usage(Faculty of Medicine, University of Kelaniya & Plan International, 2008) Herath, H.M.R.P.; Dissanayake, D.M.A.B.; Hilmi, M.A.M.; Pathmeswaran, A.; Wijesinghe, P.S.INTRODUCTION: Adolescence is a critical period of development, as adoption of unhealthy risk behaviours such as unprotected sex, smoking and drug abuse, avoiding contraceptive methods will lead to long standing health and socioeconomic consequences. Therefore information is needed about the sexual practices and contraceptive usage of adolescents and young adults to develop interventions in the community. This study was undertaken to describe and compare the sexual practices, knowledge and usage of contraceptives by adolescents and young adults in selected urban and rural settings.METHOD: This cross sectional descriptive study was conducted among young adults aged less than 21 years at the time of interview in three settings in both rural and urban areas. The study subjects were students from universities, technical colleges and garment factory workers representing both rural and urban areas. The data was collected using a pretested self administered questionnaire during June 2007 to August 2007. Information collected included marital status, gender and the level of education, first sexual relationship (age, partner, contraception used), current contraceptive practices and knowledge about contraceptive methods. The data was analysed using SPSS 10.1 statistical package. Informed consent was obtained from all participants. RESULTS : There were a total of 1258 subjects who had returned the completed questionnaires. Out of them there were 290 garment factory employees, 480 technical college students, and 488 university students. The percentage of females was 58.9%. The mean ages of the males and the females of the total population were 20.75(50 1.13) years and 20.55(SD 1.63) and it was similar in the three settings. The level of education was highest among the undergraduates lowest among garment factory workers. Out of the population 303 (24.1%) were sexually active. It was significantly higher among males {33.5%0 than females (17.0%). Both among male and females this trend was significantly more common among garment factory workers. Sexual activity of the unmarried and the premarital sexual practices of married subjects are shown in the table. 6. 17% of females and 33.5% of males were sexually active before marriage. 90% male garment factory workers were sexually active. In contrast the proportionItem Characteristics of menarche in adolescent girls in Sri Lanka(Faculty of Medicine, University of Kelaniya & Plan International, 2008) Salgado, L.S.S.; Abeysuriya, V.; Wickremasinghe, A.R.INTRODUCTION: Menarche is an important biological milestone in girls. The age at attainment of menarche is important for implementing programmes to improve the life skills of girls. OBJECTIVE: To describe the characteristics of menarche, the factors influencing the onset of menarche and to describe the knowledge, beliefs and practices during menarche of adolescent girls in Sri Lanka. Methods: This cross sectional study was conducted among girls 10-16 years of age in four schools situated in the Ragama Medical Officer of Health (MOH) area. Six hundred and sixty two girls were randomly selected and data were collected using a pre-tested, self-administered questionnaire. RESULTS: The median age of our sample was 13 years (range 10-16 years); the mean and median ages of attaining menarche were 12,53 and 11,48 years respectively. The mean BMI of girls who had attained menarche was 17.6 (SEM 0.22) Kg/m2 and those who did not was 16.92 (SEM 0.32) Kg/m2. 47% of the girls had a menstrual cycle length of e" 29 days, 23.4% had irregular cycles and 59% reported that the duration of bleeding was 3-5 days. First borns reported a IcJwer mean age at menarche (12.34 years) than the later borns (12.6 years) (p=0.02). Girls from single child families, who were from higher social categories (Categories 1 & 2) and whose parents were educated beyond 0/L attained menarche earlier. 40.8% stated that menstrual blood is not dirty, 70% admitted that there was no prohibition of having cold or sour foods. The majority of the students had adequate knowledge regarding physical changes during menarche. Girls experienced negative emotions during menstruation. CONCLUSION: The median age of attaining menarche is 11.48 years. Girls experienced negative emotions during menstruation.