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Browsing Conference Papers by Author "Premawardhena, A.P."

Browsing Conference Papers by Author "Premawardhena, A.P."

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  • 20 year follow up and survival analysis in a cohort of patients with Haemoglobin E beta Thalassaemia. 
    Olivieri, N.F.; Premawardhena, A.P.; Amir-Arsalan, S.; Ediriweera, D.; Mettananda, S.; Bandara, W.D.; Arambepola, M.; de Silva, S.; Refai, M.A.C.M.; Allen, A. (Sri Lanka Medical Association., 2019)
    INTRODUCTION & OBJECTIVES: Haemoglobin E beta thalassaemia (EBT) is the commonest beta thalassaemia syndrome in the world and is extremely phenotypically variable. Unlike for transfusion dependent thalassaemia (TDT) there ...
  • Assessing liver fibrosis in patients with transfusion dependent beta thalassaemia - a predictive model 
    Padeniya, A.G.P.M.; Ediriweera, D.; de Silva, A.; Niriella, M.A.; Premawardhena, A.P. (Sri Lanka Medical Association, 2021)
    Introduction and Objectives Liver fibrosis in β-thalassaemia major is mainly due to transfusion-related iron overload. Transient elastography (TE) is an imaging modality which measures liver stiffness/fibrosis non-invasively. ...
  • Assessing reversibility of liver fibrosis in patients with transfusion-dependent beta thalassaemia following intensive chelation 
    Padeniya, A.G.P.M.; Ediriweera, D.; Niriella, M.A.; de Silva, A.; Premawardhena, A.P. (Sri Lanka Medical Association, 2023)
    INTRODUCTION: Transfusion-related iron overload is a leading cause of hepatic fibrosis in transfusion-dependent thalassaemia (TDT). OBJECTIVES: This study aimed to evaluate the reversibility of liver fibrosis with intensive ...
  • Cardiac functions in older patients with haemoglobin E- β thalassaemia 
    Premawardhena, A.P.; Wanninayake, S.; Dolapihilla, S.N.; Kapuruge, L.; Katugaha, N.; Olivieri, N.F.; Weatherall, D.J. (Sri Lanka Medical Association, 2007)
    INTRODUCTION: Cardiac disease accounts for most deaths in patients with thalassaemia. Little is known about cardiac functions in ageing patients with thalassaemia OBJECTIVE: To study cardiac functions in older patients ...
  • Chracterisation of beta giobin mutations in Sri Lankan patients with betathalassaemia intermedia 
    Perera, S.; Silva, D.P.S.I.; Hapugoda, M.; Wickramarathne, M.N.; Wijesirwardhena, I.; Efremove, D.G.; Fisher, C.A.; Weatherall, D.J.; Premawardhena, A.P. (Sri Lanka Medical Association, 2013)
    INTRODUCTION AND OBJECTIVES: Patients with beta thalassaemia intermedia account for a third of patients attending thalassaemia clinics in Sri Lanka. They show immense phenotypic diversity, the genetic basis for which has ...
  • The clinical effects of excessive a globin genes : two family studies 
    Premawardhena, A.P.; Fisher, C.A.; Rugless, M.; de Silva, S.; Perera, A.W.V.S.; Olivien, N.F.; Weatherall, D.J. (Sri Lanka Medical Association, 2003)
    INTRODUCTION: Globin chain imbalance is the central pathogenic abnormality in the thalassaemias, a condition where globin gene expression is reduced. Conversely, the inheritance of excess globin genes too may affect the ...
  • Do thalassaemic patients, their parents and caregivers support termination of pregnancy as a method for thalassaemia prevention? 
    Nandasiri, A.S.D.; Dissakaruna, A.M.D.D.; Silva, D.P.S.I.; Nishad, A.A.N.; Premawardhena, A.P. (Sri Lanka Medical Association, 2011)
    INTRODUCTION AND OBJECTIVES: The only proven way to prevent thalassaemia, the commonest monogenic disease in Sri Lanka, is premarital and ante natal counselling followed by pre-natal diagnosis (PND) and termination of ...
  • Familial thrombocytopaenia in three male siblings 
    Amarasena, P.; Premawardhena, A.P.; Herath, H.R.B.M.; Seneviratne, S.L. (Sri Lanka Medical Association, 2017)
    INTRODUCTION & OBJECTIVES: Familial thrombocytopaenia is uncommon. Specific molecular defects have been identified in some families. We describe three male siblings with thrombocytopaenia and other immune related findings. ...
  • Genetic origin and clinical variability of sickle cell disease in Sri Lanka 
    Darshana, L.G.T.; Bandara, W.D.M.S.; Nawaratna, U.S.B.; Costa, Y. J.; Nizri, A.H.M.; Silva, D.P.S. l.; de Silva, T.U.N.; Pushpakumara, K.P.C.; Pathirage, S.P.; Manamperi, A.; Premawardhena, A.P. (Sri Lanka Medical Association, 2018)
    INTRODUCTION AND OBJECTIVES: Sickle cell disease (SCD) is found at a low prevalence In Sri Lanka. A recent hospital based survey identified 60 patients in the country The clinical spectrum of SCD in Sri Lanka ...
  • HCV and HBV infection among a cohort of Sri Lankan thalassaemic patients 
    Perera, P.S.; Niriella, M.A.; Peries, M.A.C.; Nelumdeniya, U.B.; Dissanayake, D.M.R.; de Silva, D.S.I.; de Silva, H.J.; Premawardhena, A.P. (Sri Lanka Medical Association, 2015)
    INTRODUCTION AND OBJECTIVES: Previous studies suggest that prevalence of hepatitis C (HCV) and hepatitis B (HBV) virus infections is low in Sri Lanka. Patients with severe thalassaemia are at risk of developing blood borne ...
  • An islandwide hospital based epidemiological survey of haemoglobinopathies and an assessment of standards of care in 23 centres 
    Premawardhena, A.P.; Mudiyanse, R.M.; Jifri, M.N.; Nelumdeniya, U.B.P.; Silva, D.P.S.I.; Nizri, A.H.M.; Rajiyah, M.O.F.; de Silva, T.U.N.; Pushpakumara, K.R.C.; Dissanayake, D.M.R.; Jansz, M.; Rifaya, M.I.; Navarathne, N.M.U.S.B.; Arambepola, W.W.M.M.; Thirukumaran, V.; Mendis, D.; Weerasekara, K.P.; de Silva, N.N.; Vaidyanatha, U.S.de.S.; Mettananda, D.S.G.; Oliveri, N.F.; Weatherall, D.J. (Sri Lanka Medical Association, 2017)
    INTRODUCTION & OBJECTIVES: There is no database for haemoglobinopathy patients in Sri Lanka resulting in imprecise knowledge about the distribution and standards of care among patients managed in different centres in the ...
  • Liver dysfunction and its outcome in patients with dengue infection 
    Kumarasena, R.S.; de Silva, A.P.; Keragala, B.S.D.P.; Premaratna, B.A.H.R.; Premawardhena, A.P.; Jayamanna, S.F.; de Silva, H.J.; de Silva, S.T. (Sri Lanka Medical Association, 2010)
    OBJECTIVES: To determine the frequency and severity of liver dysfunction due to dengue infection among hospitalised patients. METHOD: A retrospective, descriptive study was done at University Medical Unit, Colombo North ...
  • Low dose subcutaneous adrenaline to prevent acute adverse reactions to antivenom serum in snake bite patients 
    Premawardhena, A.P.; de Silva, C.E.; Fonseka, M.M.D.; de Silva, H.J. (Sri Lanka Medical Association, 1999)
    OBJECTIVE: To test efficacy and safety of low dose adrenaline as pretreatment for prevention of such reactions to AVS in patients with snake bite envenoming. METHODS: A prospective, randomized, double-blind, placebo ...
  • Marriage patterns in Sri Lanka and the role of consanguinity in thalassaemia: A cross sectional descriptive analysis 
    Goonatilleke, M.D.D.C.; de Silva, S.T.; Rodrigo, R.; Perera, S.; Goonathilaka, G.W.M.R.G.B.; Ramees, L.; Mettananda, S.; Weatherall, D.L.; Premawardhena, A.P. (Sri Lanka Medical Association, 2019)
    INTRODUCTION & OBJECTIVES: Consanguineous marriages play an important role in the propagation of thalassaemia. There is a paucity of data on consanguineous marriages in modern Sri Lankan society and its effect on ...
  • Micro mapping of common alpha thalassaemia deletions (3.7 kb, 4.2 kb) in Sri Lanka and assessment of the contribution of alpha thalassemia to hypochromic microcytosis 
    Rodriao, B.K.R.P.; Perera, H.L.; Branava, U.; Manamperi, A.A.P.S.; Weatherall, D.J.; Premawardhena, A.P. (Sri Lanka Medical Association, 2014)
    INTRODUCTION AND OBJECTIVES: The exact prevalence and distribution of a thalassaemia in Sri-Lanka is not known, and it is widely believed that single gene deletion of a thalassaemia does not cause hypochromic rnicrocytic ...
  • Paraspinal extramcduallry erythropoiesis- a rare cause of spinal cord compression: two case reports 
    Arambepola, M.; Premawardhena, A.P.; de Silva, S.; Olivieri, N.; Weatherall, D.J. (Sri Lanka Medical Association, 2004)
    INTRODUCTION: Extrameduallry erythropoiesis (EME) is characterized by the appearance of haemopoietic tissue outside the bone marrow. When EME occurs, albeit rarely, outside the liver and spleen problems may occur. We ...
  • Parental awareness and cascade screening of thalassaemia 
    Nishad, A.A.N.; Premawardhena, A.P. (Sri Lanka Medical Association, 2010)
    INTRODUCTION: A strategy to prevent new births with thalassaemia major in countries where abortion is illegal is to screen the at risk population for the carrier state and advocating "safe marriages". One of the highest ...
  • Pseudo polycythaemia and its association with cardio-metabolic risk factors: A preliminary descriptive analysis from a tertiary care hospital 
    de Silva, S.T.; Amarasena, P.; Dias, M.A.D.H.; Lakmini, K.M.S.; Premathilaka, L.H.R.A.; Ranatunga, R.J.K.L.D.; Moratuwegama, H.M.D.; Siriwardana, S.R.; Niriella, M.A.; Premawardhena, A.P. (Sri Lanka Medical Association, 2018)
    INTRODUCTION AND OBJECTIVES: Polycythaemia is the result of either an actual increase in red cell mass (true) or relative reduction in plasma volume (spurious). Spurious or pseudo-polycythaemia (PP) is a poorly-researched ...
  • Pulmonary arterial hypertension in thalassaemia patients- does splenectomy and disease severity increase the risk? 
    Premawardana, N.P.; Nandasiri, A.S.D.; Ranaweera, A.G.R.M.A.; Nishad, A.A.N.; Silva, D.P.S.I.; Premawardhena, A.P. (Sri Lanka Medical Association, 2011)
    INTRODUCTION AND OBJECTIVES: Pulmonary arterial hypertension (PAH) has been described in patients with thalassaemia. A causative association with splenectomy has been postulated. Our previous observations differed from ...
  • Response of jaundice to phenobarbitone in thalassaemic patients co-inheriting Gilbert syndrome 
    Premawardhena, A.P.; Arambepola, M.; Fisher, C.A.; Oliveiri, N.F.; Weatherall, D.J. (Sri Lanka Medical Association, 2004)
    INTRODUCTION: Genetic mutations causing Gilbert's syndrome are found in up to 20% of Sri Lankans. The co-existence of Gilbert's syndrome together with haemolytic anaemias can lead to significantly higher level of serum ...

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