dc.contributor.author |
Muthugala, R. |
|
dc.contributor.author |
Dheerasekara, K. |
|
dc.contributor.author |
Manamperi, A. |
|
dc.contributor.author |
Gunasena, S. |
|
dc.contributor.author |
Galagoda, G. |
|
dc.date.accessioned |
2022-05-04T06:29:38Z |
|
dc.date.available |
2022-05-04T06:29:38Z |
|
dc.date.issued |
2022 |
|
dc.identifier.citation |
Japanese Journal of Infectious Diseases.2022.;75(5):533-536 [Epub 2022 Apr 28] |
en_US |
dc.identifier.issn |
1344-6304 |
|
dc.identifier.uri |
http://repository.kln.ac.lk/handle/123456789/24573 |
|
dc.description |
Indexed in MEDLINE. |
en_US |
dc.description.abstract |
Hantavirus; Hemorrhagic fever with renal syndrome (HFRS) is an emerging zoonotic disease in Euro-Asia which is clinically indistinguishable from leptospirosis. A total number of 1032 patients were included in the analysis from March 2013 to March 2021 with the clinical suspicion of HFRS-like illness. Of them, 168 patients were positive for hantavirus IgM antibodies. Thirty-one patients out of 35 patients had given a four-fold rise IgG antibody titre with paired serum confirming the acute hantavirus infections. Detected antibodies showed a diverse pattern, strongly cross-reacting with Seoul, Hantaan and Puumala virus antigens. All the IgM positive patients had no serological evidence of acute dengue or leptospirosis and had classical features of HFRS; fever, thrombocytopenia and renal involvement. More than 90% of patients had a history of rodent exposure 2-3 weeks prior to the onset of the fever. The highest number of positive cases were diagnosed from the Western and North-Central Provinces of Sri Lanka during the paddy harvesting seasons. A significant number of patients had developed severe complications with a high mortality rate. Therefore, hantavirus infection should be considered as a differential diagnosis for leptospirosis-like illness in Sri Lanka. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
National Institute of Infectious Diseases |
en_US |
dc.subject |
HFRS |
en_US |
dc.subject |
Hantavirus |
en_US |
dc.subject |
Sri Lanka |
en_US |
dc.title |
Hantavirus Hemorrhagic Fever with Renal Syndrome (HFRS) - Suspected cases in Sri Lanka; clinical picture and epidemiology from 2013-2021 |
en_US |
dc.type |
Article |
en_US |