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Clozapine induced severe weight loss in resistant schizophrenia managed with risperidone add-on therapy

Clozapine induced severe weight loss in resistant schizophrenia managed with risperidone add-on therapy

Chandradasa, M.; Kuruppuarachchi, C.S.; Rathnayake, L.C.; Kuruppuarachchi, K.A.L.A.
URI: http://repository.kln.ac.lk/handle/123456789/22007
Citation: Sri Lanka Journal of Psychiatry.2020; 11(2): 38–39.
Date: 2020

Abstract:

ABSTRACT: Clozapine is prescribed for resistant schizophrenia. It is usually associated with weight gain. There have been only a few reports of weight loss associated with clozapine treatment and we report two patients from Sri Lanka. The first patient lost 27% of bodyweight on clozapine while the second lost 17%. Both were clinically stable on clozapine, with marked reduction of psychotic symptoms. Adding risperidone helped to regain the lost weight in the described patients. KEYWORDS: Clozapine, Weight, Schizophrenia, Sri Lanka

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