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Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection

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dc.contributor.author Blacksell, S.D. en_US
dc.contributor.author Tanganuchitcharnchai, A. en_US
dc.contributor.author Jarman, R.G. en_US
dc.contributor.author Gibbons, R.V. en_US
dc.contributor.author Paris, D.H. en_US
dc.contributor.author Bailey, M.S. en_US
dc.contributor.author Day, N.P. en_US
dc.contributor.author Premaratna, R. en_US
dc.contributor.author Lalloo, D.G. en_US
dc.contributor.author de Silva, H.J. en_US
dc.date.accessioned 2014-10-29T09:32:15Z
dc.date.available 2014-10-29T09:32:15Z
dc.date.issued 2011 en_US
dc.identifier.citation Clinical and Vaccine Immunology; 18(10): pp.1773-75 en_US
dc.identifier.issn 1556-6811 (Print) en_US
dc.identifier.issn 1556-679X (Electronic) en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/2035
dc.description.abstract A Sri Lankan fever cohort (n = 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a convalescent sample SN of 84% and an SP of 91%. These assays are not suitable for the acute diagnosis of Chikungunya virus infection.
dc.publisher American Society for Microbiology en_US
dc.title Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection en_US
dc.type Article en_US
dc.creator.corporateauthor American Society for Microbiology en_US


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