Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

Kilpeläinen, T.O.; Bentley, A.R.; Noordam, R.; Sung, Y. J.; Schwander, K.; Winkler, T. W.; Jakupović, H.; Chasman, D. I.; Manning, A.; Ntalla, I.; Aschard, H.; Brown, M. R.; de Las Fuentes, L.; Franceschini, N.; Guo, X.; Vojinovic, D.; Aslibekyan, S.; Feitosa, M. F.; Kho, M.; Musani, S. K.; Richard, M.; Wang, H.; Wang, Z.; Bartz, T. M.; Bielak, L. F.; Campbell, A.; Dorajoo, R.; Fisher, V.; Hartwig, F. P.; Horimoto, A. R. V. R.; Li, C.; Lohman, K. K.; Marten, J.; Sim, X.; Smith, A. V.; Tajuddin, S. M.; Alver, M.; Amini, M.; Boissel, M.; Chai, J. F.; Chen, X.; Divers, J.; Evangelou, E.; Gao, C.; Graff, M.; Harris, S. E.; He, M.; Hsu, F. C.; Jackson, A. U.; Zhao, J. H.; Kraja, A. T.; Kühnel, B.; Laguzzi, F.; Lyytikäinen, L. P.; Nolte, I. M.; Rauramaa, R.; Riaz, M.; Robino, A.; Rueedi, R.; Stringham, H. M.; Takeuchi, F.; van der Most, P. J.; Varga, T. V.; Verweij, N.; Ware, E. B.; Wen, W.; Li, X.; Yanek, L. R.; Amin, N.; Arnett, D. K.; Boerwinkle, E.; Brumat, M.; Cade, B.; Canouil, M.; Chen, Y. I.; Concas, M. P.; Connell, J.; de Mutsert, R.; de Silva, H.J.; de Vries, P.S.; Demirkan, A.; Ding, J.; Eaton, C. B.; Faul, J. D.; Friedlander, Y.; Gabriel, K. P.; Ghanbari, M.; Giulianini, F.; Gu, C. C.; Gu, D.; Harris, T. B.; He J, J.; Heikkinen, S.; Heng, C. K.; Hunt, S. C.; Ikram, M. A.; Jonas, J. B.; Koh, W. P.; Komulainen, P.; Krieger, J. E.; Kritchevsky, S. B.; Kutalik, Z.; Kuusisto, J.; Langefeld, C. D.; Langenberg, C.; Launer, L. J.; Leander, K.; Lemaitre, R. N.; Lewis, C. E.; Liang, J.; Lifelines Cohort Study; Liu, J.; Mägi, R.; Manichaikul, A.; Meitinger, T.; Metspalu, A.; Milaneschi, Y.; Mohlke, K. L.; Mosley, T. H.; Murray, A. D.; Nalls, M. A.; Nang, E. K.; Nelson, C. P.; Nona, S.; Norris, J. M.; Nwuba, C. V.; O'Connell, J.; Palmer, N. D.; Papanicolau, G. J.; Pazoki, R.; Pedersen, N. L.; Peters, A.; Peyser, P. A.; Polasek, O.; Porteous, D. J.; Poveda, A.; Raitakari, O. T.; Rich, S. S.; Risch, N.; Robinson, J. G.; Rose, L. M.; Rudan, I.; Schreiner, P. J.; Scott, R. A.; Sidney, S. S.; Sims, M.; Smith, J. A.; Snieder, H.; Sofer, T.; Starr, J. M.; Sternfeld, B.; Strauch, K.; Tang, H.; Taylor, K. D.; Tsai, M. Y.; Tuomilehto, J.; Uitterlinden, A. G.; van der Ende, M. Y.; van Heemst, D.; Voortman, T.; Waldenberger, M.; Wennberg, P.; Wilson, G.; Xiang, Y. B.; Yao, J.; Yu, C.; Yuan, J. M.; Zhao, W.; Zonderman, A. B.; Becker, D. M.; Boehnke, M.; Bowden, D. W.; de Faire, U.; Deary, I. J.; Elliott, P.; Esko, T.; Freedman, B. I.; Froguel, P.; Gasparini, P.; Gieger, C.; Kato, N.; Laakso, M.; Lakka, T. A.; Lehtimäki, T.; Magnusson, P. K. E.; Oldehinkel, A. J.; Penninx, B. W. J. H.; Samani, N. J.; Shu, X. O.; van der Harst, P.; Van Vliet-Ostaptchouk, J. V.; Vollenweider, P.; Wagenknecht, L. E.; Wang, Y. X.; Wareham, N. J.; Weir, D. R.; Wu, T.; Zheng, W.; Zhu, X.; Evans, M. K.; Franks, P. W.; Gudnason, V.; Hayward, C.; Horta, B. L.; Kelly, T. N.; Liu, Y.; North, K. E.; Pereira, A. C.; Ridker, P. M.; Tai, E. S.; van Dam, R. M.; Fox, E. R.; Kardia, S. L. R.; Liu, C. T.; Province, M. A.; Mook-Kanamori, D. O.; Redline, S.; van Duijn, C. M.; Rotter, J. I.; Kooperberg, C. B.; Gauderman, W. J.; Psaty, B. M.; Rice, K.; Munroe, P. B.; Fornage, M.; Cupples, L. A.; Rotimi, C. N.; Morrison, A. C.; Rao, D. C.; Loos, R. J. F.

dc.contributor.author	Kilpeläinen, T.O.
dc.contributor.author	Bentley, A.R.
dc.contributor.author	Noordam, R.
dc.contributor.author	Sung, Y. J.
dc.contributor.author	Schwander, K.
dc.contributor.author	Winkler, T. W.
dc.contributor.author	Jakupović, H.
dc.contributor.author	Chasman, D. I.
dc.contributor.author	Manning, A.
dc.contributor.author	Ntalla, I.
dc.contributor.author	Aschard, H.
dc.contributor.author	Brown, M. R.
dc.contributor.author	de Las Fuentes, L.
dc.contributor.author	Franceschini, N.
dc.contributor.author	Guo, X.
dc.contributor.author	Vojinovic, D.
dc.contributor.author	Aslibekyan, S.
dc.contributor.author	Feitosa, M. F.
dc.contributor.author	Kho, M.
dc.contributor.author	Musani, S. K.
dc.contributor.author	Richard, M.
dc.contributor.author	Wang, H.
dc.contributor.author	Wang, Z.
dc.contributor.author	Bartz, T. M.
dc.contributor.author	Bielak, L. F.
dc.contributor.author	Campbell, A.
dc.contributor.author	Dorajoo, R.
dc.contributor.author	Fisher, V.
dc.contributor.author	Hartwig, F. P.
dc.contributor.author	Horimoto, A. R. V. R.
dc.contributor.author	Li, C.
dc.contributor.author	Lohman, K. K.
dc.contributor.author	Marten, J.
dc.contributor.author	Sim, X.
dc.contributor.author	Smith, A. V.
dc.contributor.author	Tajuddin, S. M.
dc.contributor.author	Alver, M.
dc.contributor.author	Amini, M.
dc.contributor.author	Boissel, M.
dc.contributor.author	Chai, J. F.
dc.contributor.author	Chen, X.
dc.contributor.author	Divers, J.
dc.contributor.author	Evangelou, E.
dc.contributor.author	Gao, C.
dc.contributor.author	Graff, M.
dc.contributor.author	Harris, S. E.
dc.contributor.author	He, M.
dc.contributor.author	Hsu, F. C.
dc.contributor.author	Jackson, A. U.
dc.contributor.author	Zhao, J. H.
dc.contributor.author	Kraja, A. T.
dc.contributor.author	Kühnel, B.
dc.contributor.author	Laguzzi, F.
dc.contributor.author	Lyytikäinen, L. P.
dc.contributor.author	Nolte, I. M.
dc.contributor.author	Rauramaa, R.
dc.contributor.author	Riaz, M.
dc.contributor.author	Robino, A.
dc.contributor.author	Rueedi, R.
dc.contributor.author	Stringham, H. M.
dc.contributor.author	Takeuchi, F.
dc.contributor.author	van der Most, P. J.
dc.contributor.author	Varga, T. V.
dc.contributor.author	Verweij, N.
dc.contributor.author	Ware, E. B.
dc.contributor.author	Wen, W.
dc.contributor.author	Li, X.
dc.contributor.author	Yanek, L. R.
dc.contributor.author	Amin, N.
dc.contributor.author	Arnett, D. K.
dc.contributor.author	Boerwinkle, E.
dc.contributor.author	Brumat, M.
dc.contributor.author	Cade, B.
dc.contributor.author	Canouil, M.
dc.contributor.author	Chen, Y. I.
dc.contributor.author	Concas, M. P.
dc.contributor.author	Connell, J.
dc.contributor.author	de Mutsert, R.
dc.contributor.author	de Silva, H.J.
dc.contributor.author	de Vries, P.S.
dc.contributor.author	Demirkan, A.
dc.contributor.author	Ding, J.
dc.contributor.author	Eaton, C. B.
dc.contributor.author	Faul, J. D.
dc.contributor.author	Friedlander, Y.
dc.contributor.author	Gabriel, K. P.
dc.contributor.author	Ghanbari, M.
dc.contributor.author	Giulianini, F.
dc.contributor.author	Gu, C. C.
dc.contributor.author	Gu, D.
dc.contributor.author	Harris, T. B.
dc.contributor.author	He J, J.
dc.contributor.author	Heikkinen, S.
dc.contributor.author	Heng, C. K.
dc.contributor.author	Hunt, S. C.
dc.contributor.author	Ikram, M. A.
dc.contributor.author	Jonas, J. B.
dc.contributor.author	Koh, W. P.
dc.contributor.author	Komulainen, P.
dc.contributor.author	Krieger, J. E.
dc.contributor.author	Kritchevsky, S. B.
dc.contributor.author	Kutalik, Z.
dc.contributor.author	Kuusisto, J.
dc.contributor.author	Langefeld, C. D.
dc.contributor.author	Langenberg, C.
dc.contributor.author	Launer, L. J.
dc.contributor.author	Leander, K.
dc.contributor.author	Lemaitre, R. N.
dc.contributor.author	Lewis, C. E.
dc.contributor.author	Liang, J.
dc.contributor.author	Lifelines Cohort Study
dc.contributor.author	Liu, J.
dc.contributor.author	Mägi, R.
dc.contributor.author	Manichaikul, A.
dc.contributor.author	Meitinger, T.
dc.contributor.author	Metspalu, A.
dc.contributor.author	Milaneschi, Y.
dc.contributor.author	Mohlke, K. L.
dc.contributor.author	Mosley, T. H.
dc.contributor.author	Murray, A. D.
dc.contributor.author	Nalls, M. A.
dc.contributor.author	Nang, E. K.
dc.contributor.author	Nelson, C. P.
dc.contributor.author	Nona, S.
dc.contributor.author	Norris, J. M.
dc.contributor.author	Nwuba, C. V.
dc.contributor.author	O'Connell, J.
dc.contributor.author	Palmer, N. D.
dc.contributor.author	Papanicolau, G. J.
dc.contributor.author	Pazoki, R.
dc.contributor.author	Pedersen, N. L.
dc.contributor.author	Peters, A.
dc.contributor.author	Peyser, P. A.
dc.contributor.author	Polasek, O.
dc.contributor.author	Porteous, D. J.
dc.contributor.author	Poveda, A.
dc.contributor.author	Raitakari, O. T.
dc.contributor.author	Rich, S. S.
dc.contributor.author	Risch, N.
dc.contributor.author	Robinson, J. G.
dc.contributor.author	Rose, L. M.
dc.contributor.author	Rudan, I.
dc.contributor.author	Schreiner, P. J.
dc.contributor.author	Scott, R. A.
dc.contributor.author	Sidney, S. S.
dc.contributor.author	Sims, M.
dc.contributor.author	Smith, J. A.
dc.contributor.author	Snieder, H.
dc.contributor.author	Sofer, T.
dc.contributor.author	Starr, J. M.
dc.contributor.author	Sternfeld, B.
dc.contributor.author	Strauch, K.
dc.contributor.author	Tang, H.
dc.contributor.author	Taylor, K. D.
dc.contributor.author	Tsai, M. Y.
dc.contributor.author	Tuomilehto, J.
dc.contributor.author	Uitterlinden, A. G.
dc.contributor.author	van der Ende, M. Y.
dc.contributor.author	van Heemst, D.
dc.contributor.author	Voortman, T.
dc.contributor.author	Waldenberger, M.
dc.contributor.author	Wennberg, P.
dc.contributor.author	Wilson, G.
dc.contributor.author	Xiang, Y. B.
dc.contributor.author	Yao, J.
dc.contributor.author	Yu, C.
dc.contributor.author	Yuan, J. M.
dc.contributor.author	Zhao, W.
dc.contributor.author	Zonderman, A. B.
dc.contributor.author	Becker, D. M.
dc.contributor.author	Boehnke, M.
dc.contributor.author	Bowden, D. W.
dc.contributor.author	de Faire, U.
dc.contributor.author	Deary, I. J.
dc.contributor.author	Elliott, P.
dc.contributor.author	Esko, T.
dc.contributor.author	Freedman, B. I.
dc.contributor.author	Froguel, P.
dc.contributor.author	Gasparini, P.
dc.contributor.author	Gieger, C.
dc.contributor.author	Kato, N.
dc.contributor.author	Laakso, M.
dc.contributor.author	Lakka, T. A.
dc.contributor.author	Lehtimäki, T.
dc.contributor.author	Magnusson, P. K. E.
dc.contributor.author	Oldehinkel, A. J.
dc.contributor.author	Penninx, B. W. J. H.
dc.contributor.author	Samani, N. J.
dc.contributor.author	Shu, X. O.
dc.contributor.author	van der Harst, P.
dc.contributor.author	Van Vliet-Ostaptchouk, J. V.
dc.contributor.author	Vollenweider, P.
dc.contributor.author	Wagenknecht, L. E.
dc.contributor.author	Wang, Y. X.
dc.contributor.author	Wareham, N. J.
dc.contributor.author	Weir, D. R.
dc.contributor.author	Wu, T.
dc.contributor.author	Zheng, W.
dc.contributor.author	Zhu, X.
dc.contributor.author	Evans, M. K.
dc.contributor.author	Franks, P. W.
dc.contributor.author	Gudnason, V.
dc.contributor.author	Hayward, C.
dc.contributor.author	Horta, B. L.
dc.contributor.author	Kelly, T. N.
dc.contributor.author	Liu, Y.
dc.contributor.author	North, K. E.
dc.contributor.author	Pereira, A. C.
dc.contributor.author	Ridker, P. M.
dc.contributor.author	Tai, E. S.
dc.contributor.author	van Dam, R. M.
dc.contributor.author	Fox, E. R.
dc.contributor.author	Kardia, S. L. R.
dc.contributor.author	Liu, C. T.
dc.contributor.author	Province, M. A.
dc.contributor.author	Mook-Kanamori, D. O.
dc.contributor.author	Redline, S.
dc.contributor.author	van Duijn, C. M.
dc.contributor.author	Rotter, J. I.
dc.contributor.author	Kooperberg, C. B.
dc.contributor.author	Gauderman, W. J.
dc.contributor.author	Psaty, B. M.
dc.contributor.author	Rice, K.
dc.contributor.author	Munroe, P. B.
dc.contributor.author	Fornage, M.
dc.contributor.author	Cupples, L. A.
dc.contributor.author	Rotimi, C. N.
dc.contributor.author	Morrison, A. C.
dc.contributor.author	Rao, D. C.
dc.contributor.author	Loos, R. J. F.
dc.date.accessioned	2019-02-22T10:24:52Z
dc.date.available	2019-02-22T10:24:52Z
dc.date.issued	2019
dc.identifier.citation	Nature communications.2019;10(1):376	en_US
dc.identifier.issn	2041-1723 (Electronic)
dc.identifier.uri	http://repository.kln.ac.lk/handle/123456789/19997
dc.description	indexed in Medline	en_US
dc.description.abstract	Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.	en_US
dc.language.iso	en	en_US
dc.publisher	Nature Publications	en_US
dc.subject	Blood lipid levels	en_US
dc.title	Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.	en_US
dc.type	Article	en_US