dc.contributor.author |
Sanagapalli, S. |
|
dc.contributor.author |
Ko, Y. |
|
dc.contributor.author |
Kariyawasam, V. |
|
dc.contributor.author |
Ng, S.C. |
|
dc.contributor.author |
Tang, W. |
|
dc.contributor.author |
de Silva, H.J. |
|
dc.contributor.author |
Chen, M. |
|
dc.contributor.author |
Wu, K. |
|
dc.contributor.author |
Aniwan, S. |
|
dc.contributor.author |
Ng, K.K. |
|
dc.contributor.author |
Ong, D. |
|
dc.contributor.author |
Ouyang, Q. |
|
dc.contributor.author |
Hilmi, I. |
|
dc.contributor.author |
Simadibrata, M. |
|
dc.contributor.author |
Pisespongsa, P. |
|
dc.contributor.author |
Gopikrishna, S. |
|
dc.contributor.author |
Leong, R.W. |
|
dc.contributor.author |
IBD Sydney Organization and the asia-Pacific Crohn's Epidemiology Study (ACCESS) Group |
|
dc.date.accessioned |
2019-01-03T04:52:36Z |
|
dc.date.available |
2019-01-03T04:52:36Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
Intestinal Research. 2018;16(3): 409-415 |
en_US |
dc.identifier.issn |
2288-1956 (Electronic) |
|
dc.identifier.issn |
1598-9100 (Print) |
|
dc.identifier.issn |
1598-9100 (Linking) |
|
dc.identifier.uri |
http://repository.kln.ac.lk/handle/123456789/19267 |
|
dc.description |
|
en |
dc.description |
Indexed in Scopus; In PUBMED; Indexed in MEDLINE |
en |
dc.description.abstract |
BACKGROUND/AIMS: To examine the association between use of oral contraceptive pills (OCPs) and the risk of developing inflammatory bowel diseases (IBD), in a modern cohort. METHODS: A prospective nested case-control study across sites in the Asia-Pacific region was conducted; involving female IBD cases and asymptomatic controls. Subjects completed a questionnaire addressing questions related to OCP use. Primary outcome was the risk of development of IBD of those exposed to OCP versus non-exposure. Secondary outcomes were development of Crohn's disease (CD) versus ulcerative colitis (UC), and whether age of first use of OCP use may be associated with risk of IBD. RESULTS: Three hundred and forty-eight female IBD cases (41% CD, median age: 43 years) and 590 female age-matched controls were recruited. No significant association was found between OCP use and the risk of IBD (odds ratio [OR], 1.65; 95% confidence interval, 0.77-3.13; P=0.22), CD (OR, 1.55) or UC (OR, 1.01). The lack of association persisted when results were adjusted for age and smoking. IBD cases commenced OCP use at a younger age than controls (18 years vs. 20 years, P=0.049). CONCLUSIONS: In this large cohort of subjects from the Asia-Pacific region, we found a modest but not significantly increased risk of developing IBD amongst OCP users. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.publisher |
Korean Association for the Study of Intestinal Diseases |
en_US |
dc.subject |
Inflammatory Bowel Diseases |
en_US |
dc.subject |
Contraceptive Agents |
en |
dc.subject |
Contraceptive Agents, Hormonal |
en |
dc.subject |
Contraceptives, Oral |
en |
dc.subject |
Contraceptives, Oral-adverse effects |
en |
dc.title |
The Association between new generation oral contraceptive pill and the development of inflammatory bowel diseases |
en_US |
dc.type |
Article |
en_US |