dc.contributor.author |
Sunil-Chandra, N.P. |
|
dc.contributor.author |
Efstathiou, S. |
|
dc.contributor.author |
Nash, A.A. |
|
dc.date.accessioned |
2017-08-21T04:06:22Z |
|
dc.date.available |
2017-08-21T04:06:22Z |
|
dc.date.issued |
1992 |
|
dc.identifier.citation |
Journal of General Virology. 1992; 73(12): 3275-3279. |
en_US |
dc.identifier.issn |
0022-1317 (Print) |
|
dc.identifier.issn |
1465-2099 (Electronic) |
|
dc.identifier.issn |
0022-1317 (Linking) |
|
dc.identifier.uri |
|
|
dc.identifier.uri |
http://repository.kln.ac.lk/handle/123456789/17180 |
en |
dc.description |
Indexed in MEDLINE |
|
dc.description.abstract |
Murine gammaherpesvirus 68 (MHV-68) is able to persist in spleen cells of infected mice. To determine the cell type harbouring persistent virus, spleen cells from infected animals were separated into immunoglobulin (Ig)-positive (B cell-enriched), Ig-negative (T cellenriched) and plastic-adherent (macrophage-enriched) fractions. These cells were co-cultivated with permissive BHK-21 cells in an infectious centre assay. The consistent recovery and enrichment of infectious centres in the Ig-positive fraction clearly demonstrates that B cells are a major site of virus persistence/latency. This observation indicates that MHV-68 is biologically similar to Epstein-Barr virus and other members of the B cell lymphotropic gammaherpesvirus 1 subgroup. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Microbiology Society |
en_US |
dc.subject |
B-Lymphocytes-microbiology |
en_US |
dc.subject |
Herpesviridae-growth & development |
en_US |
dc.subject |
Herpesviridae-pathogenicity |
en_US |
dc.subject.mesh |
Gammaherpesvirinae |
|
dc.subject.mesh |
Gammaherpesvirinae-genetics |
|
dc.title |
Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo |
en_US |
dc.type |
Article |
en_US |