dc.contributor.author | Premawardhena, A.P. | en_US |
dc.contributor.author | Fisher, C.A. | en_US |
dc.contributor.author | Fathihu, F. | en_US |
dc.contributor.author | de Silva, S. | en_US |
dc.contributor.author | Perera, W. | en_US |
dc.contributor.author | Peto, T.E. | en_US |
dc.contributor.author | Olivieri, N.F. | en_US |
dc.contributor.author | Weatherall, D.J. | en_US |
dc.date.accessioned | 2014-10-29T09:19:17Z | |
dc.date.available | 2014-10-29T09:19:17Z | |
dc.date.issued | 2001 | en_US |
dc.identifier.citation | Lancet.2001; 357(9272): 1945-46 | en_US |
dc.identifier.issn | Lancet Publishing Group | en_US |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/1484 | |
dc.description.abstract | Chronic hyperbilirubinaemia, gallstone formation, and gall bladder disease are unusually common in people with haemoglobin E beta thalassaemia in Sri Lanka. To determine whether this has a genetic basis we compared the bilirubin levels and frequency of gallstones in patients with different alleles of the UGT*1 gene. There was a significantly higher bilirubin level in those with the 7/7 genotypes compared with 6/6 and 6/7 genotype (p=0.032 and 0.0015 respectively), who also appeared more prone to gallstone formation. These results suggest that the UGT*1 genotpe is of importance in the genesis of gallstones in this population of patients. | |
dc.title | Genetic determinants of jaundice and gallstones in haemoglobin E beta thalassaemia | en_US |
dc.type | Article | en_US |
dc.identifier.department | Medicine | en_US |
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