Browsing by Author "Gunaratna, Medha J."

Now showing items 1-6 of 6

Design, synthesis and evaluation of 3-hydroxy quinazolinone derivatives as urease inhibitors against Helicobacter pylori

Ruhunage, S. A.; Udukala, Dinusha N.; Gunaratna, Medha J. (Institute of Chemistry Ceylon, 2020)

Gastritis is a common virulent disease found in the present world. The main pathogen which can cause gastritis is Helicobacter pylori and the infection from this bacterium in the upper gastrointestinal tract can lead to ...
Design, synthesis, and evaluation of 2, 3-disubstituted quinazolin-4(3H)-one derivatives as urease inhibitors against Helicobacter pylori

Madujith, E. A. D. N.; Gunaratna, Medha J.; Udukala, Dinusha N. (Institute of Chemistry Ceylon, 2020)

Helicobacter pylori is a pathogenic bacterium that causes ulcers and inflammations in the stomach lining. This bacterium produces urease enzyme which catalyzes the hydrolysis of urea in the stomach to carbon dioxide gas ...
Detailed evaluation of methylated and acetylated products of cinnamon leaf oil against Aedes aegypti

Medagedara, H. K.; Paranagama, P. A.; Gunaratna, Medha J. (Institute of Chemistry Ceylon Adamantane House, Rajagiriya, Sri Lanka., 2020)

Aedes aegypti is a known vector of several viruses including Yellow fever, Dengue, Chikungunya and Zika virus. Two potential Aedes aegypti mosquito repellents; methyl eugenol and acetyl eugenol were semi-synthesized using ...
The OSMAC effect on the production of secondary metabolites by the endolichenic fungus, Curvularia trifolii

Lekamwasam, C. J.; Paranagama, P. A.; Gunaratna, Medha J. (Institute of Chemistry Ceylon Adamantane House, Rajagiriya, Sri Lanka., 2020)

Fungi are a very diverse group of organisms that can produce a vast number of pharmacologically active secondary metabolites. Fungi also have the ability to produce numerous secondary metabolites from a single strain. ...
Synthesis, evaluation and structure activity relationship study of 2-phenyl-3H-quinazolinone derivatives as urease inhibitors against Helicobacter pylori

Alwis, Y. Vindula; Gunaratna, Medha J.; Udukala, Dinusha N. (Institute of Chemistry Ceylon, 2020)

Urease is a nickel containing metalloenzyme, which catalyzes the hydrolysis of urea into ammonia and carbon dioxide. It is an essential enzyme for Helicobacter pylori, which is a bacterium that has an ability to colonize ...
Urease inhibitory activity of the leaves and fruits of Trichosanthes cucumerina Linn.

Dharmajeewa, H. D. O. P.; Gunaratna, Medha J.; Udukala, Dinusha N. (Institute of Chemistry Ceylon, 2020)

Helicobacter pylori is a bacterium found in stomach which secretes bacterial urease, a major virulent factor to cause peptic ulcers. Hence, numerous studies have been carried out to investigate urease inhibitory activity ...

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Browsing by Author "Gunaratna, Medha J."

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