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Title: | Baseline characteristics of the 4011 patients recruited into the Efficacy of Nitric Oxide in Stroke' (ENOS) trial. |
Authors: | Bath, P.M. Adami, A. Bereczki, D. Berge, E. Beridze, M. Cala, L. Casado, A. Caso, V. Chang, H.M. Christensen, H. Collins, R. Czlonkowska, A. Dineen, R.A. El Etribi, A. Ghani, A. R. Gommans, J. Koumellis, P. Laska, A. C. Lees, K. R. Navarro, J. Ntaios, G. Ozturk, S. Phillips, S. Pocock, S. Prasad, K. Scutt, P. de Silva, H.A. Szatmari, S. Díez-Tejedor E Utton, S. Wang, Y. J. Wardlaw, J.M. Whynes, D. Wong, L. Woodhouse, L Sprigg, N. ENOS Trial Investigators(36) |
Keywords: | Clinical Trial |
Issue Date: | 2014 |
Publisher: | Sage Publications |
Citation: | International Journal of Stroke. 2014; 9(6): 711-20. |
Abstract: | BACKGROUND: High blood pressure is common in acute stroke and associated with a worse functional outcome. Many patients who present with acute stroke are taking prescribed antihypertensive therapy before their stroke. AIMS: ENOS tested whether lowering blood pressure and continuing pre-stroke antihypertensive therapy are each safe and effective. METHODS: This study is an international multi-centre prospective randomized single-blind blinded-endpoint parallel-group partial-factorial controlled trial of transdermal glyceryl trinitrate(a nitric oxide donor, given for seven-days) vs. no glyceryl trinitrate, and of continuing vs. stopping (temporarily for seven-days) pre-stroke antihypertensive drugs if relevant, in patients with acute ischaemic stroke or intracerebral haemorrhage and high systolic blood pressure (140–220 mmHg). RESULTS: Recruitment ran from July 2001 to October 2013. Four thousand eleven patients [2097 (52•3%) in the continue/stop arm] were recruited from 173 sites across 23 countries in 5 continents (Asia 14%, Continental Europe 16%, UK 64%). Baseline characteristics include: mean age 70 (standard deviation 12) years; male 57%; mean time from stroke to recruitment 26 (13) h; mean severity (Scandinavian Stroke Scale) 34(13) of 58; mean blood pressure 167 (19)/90 (13) mmHg; ischaemic stroke 83%; and intracerebral haemorrhage 16%. The main trial results will be presented in May 2014. The results will also be presented in updated Cochrane systematic reviews and included in individual patient data meta-analyses of all relevant randomized controlled trials. CONCLUSION: ENOS is a large completed international trial of blood pressure management in acute stroke and includes patients representative of many stroke services worldwide. |
Description: | Indexed in MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/9341 |
ISSN: | 1747-4930 (Print) 1747-4949 (Electronic) 1747-4930 (Linking) |
Appears in Collections: | Journal/Magazine Articles |
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