Please use this identifier to cite or link to this item:
http://repository.kln.ac.lk/handle/123456789/9341
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bath, P.M. | en_US |
dc.contributor.author | Adami, A. | en_US |
dc.contributor.author | Bereczki, D. | en_US |
dc.contributor.author | Berge, E. | en_US |
dc.contributor.author | Beridze, M. | en_US |
dc.contributor.author | Cala, L. | en_US |
dc.contributor.author | Casado, A. | en_US |
dc.contributor.author | Caso, V. | en_US |
dc.contributor.author | Chang, H.M. | en_US |
dc.contributor.author | Christensen, H. | en_US |
dc.contributor.author | Collins, R. | en_US |
dc.contributor.author | Czlonkowska, A. | en_US |
dc.contributor.author | Dineen, R.A. | en_US |
dc.contributor.author | El Etribi, A. | en_US |
dc.contributor.author | Ghani, A. R. | en_US |
dc.contributor.author | Gommans, J. | en_US |
dc.contributor.author | Koumellis, P. | en_US |
dc.contributor.author | Laska, A. C. | en_US |
dc.contributor.author | Lees, K. R. | en_US |
dc.contributor.author | Navarro, J. | en_US |
dc.contributor.author | Ntaios, G. | en_US |
dc.contributor.author | Ozturk, S. | en_US |
dc.contributor.author | Phillips, S. | en_US |
dc.contributor.author | Pocock, S. | en_US |
dc.contributor.author | Prasad, K. | en_US |
dc.contributor.author | Scutt, P. | en_US |
dc.contributor.author | de Silva, H.A. | en_US |
dc.contributor.author | Szatmari, S. | en_US |
dc.contributor.author | Díez-Tejedor E | en_US |
dc.contributor.author | Utton, S. | en_US |
dc.contributor.author | Wang, Y. J. | en_US |
dc.contributor.author | Wardlaw, J.M. | en_US |
dc.contributor.author | Whynes, D. | en_US |
dc.contributor.author | Wong, L. | en_US |
dc.contributor.author | Woodhouse, L | en_US |
dc.contributor.author | Sprigg, N. | en_US |
dc.contributor.author | ENOS Trial Investigators(36) | en_US |
dc.date.accessioned | 2015-08-27T12:41:02Z | en_US |
dc.date.available | 2015-08-27T12:41:02Z | en_US |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | International Journal of Stroke. 2014; 9(6): 711-20. | en_US |
dc.identifier.issn | 1747-4930 (Print) | en_US |
dc.identifier.issn | 1747-4949 (Electronic) | en_US |
dc.identifier.issn | 1747-4930 (Linking) | en_US |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/9341 | en_US |
dc.description | Indexed in MEDLINE | en_US |
dc.description.abstract | BACKGROUND: High blood pressure is common in acute stroke and associated with a worse functional outcome. Many patients who present with acute stroke are taking prescribed antihypertensive therapy before their stroke. AIMS: ENOS tested whether lowering blood pressure and continuing pre-stroke antihypertensive therapy are each safe and effective. METHODS: This study is an international multi-centre prospective randomized single-blind blinded-endpoint parallel-group partial-factorial controlled trial of transdermal glyceryl trinitrate(a nitric oxide donor, given for seven-days) vs. no glyceryl trinitrate, and of continuing vs. stopping (temporarily for seven-days) pre-stroke antihypertensive drugs if relevant, in patients with acute ischaemic stroke or intracerebral haemorrhage and high systolic blood pressure (140–220 mmHg). RESULTS: Recruitment ran from July 2001 to October 2013. Four thousand eleven patients [2097 (52•3%) in the continue/stop arm] were recruited from 173 sites across 23 countries in 5 continents (Asia 14%, Continental Europe 16%, UK 64%). Baseline characteristics include: mean age 70 (standard deviation 12) years; male 57%; mean time from stroke to recruitment 26 (13) h; mean severity (Scandinavian Stroke Scale) 34(13) of 58; mean blood pressure 167 (19)/90 (13) mmHg; ischaemic stroke 83%; and intracerebral haemorrhage 16%. The main trial results will be presented in May 2014. The results will also be presented in updated Cochrane systematic reviews and included in individual patient data meta-analyses of all relevant randomized controlled trials. CONCLUSION: ENOS is a large completed international trial of blood pressure management in acute stroke and includes patients representative of many stroke services worldwide. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Sage Publications | en_US |
dc.subject | Clinical Trial | en_US |
dc.title | Baseline characteristics of the 4011 patients recruited into the Efficacy of Nitric Oxide in Stroke' (ENOS) trial. | en_US |
dc.type | Article | en_US |
dc.identifier.department | Pharmacology | en_US |
dc.creator.corporateauthor | International Stroke Society | en_US |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.