Please use this identifier to cite or link to this item:
http://repository.kln.ac.lk/handle/123456789/24573
Title: | Hantavirus Hemorrhagic Fever with Renal Syndrome (HFRS) - Suspected cases in Sri Lanka; clinical picture and epidemiology from 2013-2021 |
Authors: | Muthugala, R. Dheerasekara, K. Manamperi, A. Gunasena, S. Galagoda, G. |
Keywords: | HFRS Hantavirus Sri Lanka |
Issue Date: | 2022 |
Publisher: | National Institute of Infectious Diseases |
Citation: | Japanese Journal of Infectious Diseases.2022.;75(5):533-536 [Epub 2022 Apr 28] |
Abstract: | Hantavirus; Hemorrhagic fever with renal syndrome (HFRS) is an emerging zoonotic disease in Euro-Asia which is clinically indistinguishable from leptospirosis. A total number of 1032 patients were included in the analysis from March 2013 to March 2021 with the clinical suspicion of HFRS-like illness. Of them, 168 patients were positive for hantavirus IgM antibodies. Thirty-one patients out of 35 patients had given a four-fold rise IgG antibody titre with paired serum confirming the acute hantavirus infections. Detected antibodies showed a diverse pattern, strongly cross-reacting with Seoul, Hantaan and Puumala virus antigens. All the IgM positive patients had no serological evidence of acute dengue or leptospirosis and had classical features of HFRS; fever, thrombocytopenia and renal involvement. More than 90% of patients had a history of rodent exposure 2-3 weeks prior to the onset of the fever. The highest number of positive cases were diagnosed from the Western and North-Central Provinces of Sri Lanka during the paddy harvesting seasons. A significant number of patients had developed severe complications with a high mortality rate. Therefore, hantavirus infection should be considered as a differential diagnosis for leptospirosis-like illness in Sri Lanka. |
Description: | Indexed in MEDLINE. |
URI: | http://repository.kln.ac.lk/handle/123456789/24573 |
ISSN: | 1344-6304 |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
75_JJID.2021.837.pdf | 432.2 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.