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DC Field | Value | Language |
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dc.contributor.author | Muthugala, R. | |
dc.contributor.author | Dheerasekara, K. | |
dc.contributor.author | Manamperi, A. | |
dc.contributor.author | Gunasena, S. | |
dc.contributor.author | Galagoda, G. | |
dc.date.accessioned | 2022-05-04T06:29:38Z | |
dc.date.available | 2022-05-04T06:29:38Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Japanese Journal of Infectious Diseases.2022.;75(5):533-536 [Epub 2022 Apr 28] | en_US |
dc.identifier.issn | 1344-6304 | |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/24573 | |
dc.description | Indexed in MEDLINE. | en_US |
dc.description.abstract | Hantavirus; Hemorrhagic fever with renal syndrome (HFRS) is an emerging zoonotic disease in Euro-Asia which is clinically indistinguishable from leptospirosis. A total number of 1032 patients were included in the analysis from March 2013 to March 2021 with the clinical suspicion of HFRS-like illness. Of them, 168 patients were positive for hantavirus IgM antibodies. Thirty-one patients out of 35 patients had given a four-fold rise IgG antibody titre with paired serum confirming the acute hantavirus infections. Detected antibodies showed a diverse pattern, strongly cross-reacting with Seoul, Hantaan and Puumala virus antigens. All the IgM positive patients had no serological evidence of acute dengue or leptospirosis and had classical features of HFRS; fever, thrombocytopenia and renal involvement. More than 90% of patients had a history of rodent exposure 2-3 weeks prior to the onset of the fever. The highest number of positive cases were diagnosed from the Western and North-Central Provinces of Sri Lanka during the paddy harvesting seasons. A significant number of patients had developed severe complications with a high mortality rate. Therefore, hantavirus infection should be considered as a differential diagnosis for leptospirosis-like illness in Sri Lanka. | en_US |
dc.language.iso | en | en_US |
dc.publisher | National Institute of Infectious Diseases | en_US |
dc.subject | HFRS | en_US |
dc.subject | Hantavirus | en_US |
dc.subject | Sri Lanka | en_US |
dc.title | Hantavirus Hemorrhagic Fever with Renal Syndrome (HFRS) - Suspected cases in Sri Lanka; clinical picture and epidemiology from 2013-2021 | en_US |
dc.type | Article | en_US |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
File | Description | Size | Format | |
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75_JJID.2021.837.pdf | 432.2 kB | Adobe PDF | View/Open |
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