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Title: Validation of the World Health Organization/ International Society of Hypertension (WHO/ISH) cardiovascular risk predictions in Sri Lankans based on findings from a prospective cohort study
Authors: Thulani, U.B.
Mettananda, K.C.D.
Warnakulasuriya, D.T.D.
Peiris, T.S.G.
Kasturiratne, K.T.A.A.
Ranawaka, U.K.
Chackrewarthy, S.
Dassanayake, A.S.
Kurukulasooriya, S.A.F.
Niriella, M.A.
de Silva, S.T.
Pathmeswaran, A.P.
Kato, N.
de Silva, H.J.
Wickremasinghe, A.R.
Keywords: Hypertension
Issue Date: 2020
Publisher: Ceylon College of Physicians
Citation: Journal of the Ceylon College of Physicians. 2020; 51(Supplement 1): 12.
Abstract: INTRODUCTION AND OBJECTIVES: There are no cardiovascular(CV)-risk prediction models specifically for Sri Lankans. Different risk prediction models not validated among Sri Lankans are being used to predict CV-risk of Sri Lankans. We validated the WHO/ISH (SEAR-B) risk prediction charts prospectively in a population-based cohort of Sri Lankans. METHOD: We selected participants between 40-64 years, by stratified random sampling of the Ragama Medical Officer of Health area in 2007 and followed them up for 10-years. Risk predictions for 10-years were calculated using WHO/ISH (SEAR-B) charts with- and without-cholesterol in 2007. We identified all new-onset cardiovascular events(CVE) from 2007-2017 by interviewing participants and perusing medical-records/death-certificates in 2017. We validated the risk predictions against observed CVEs. RESULTS: Baseline cohort consisted of 2517 participants (males 1132 (45%), mean age 53.7 (SD: 6.7 years). We observed 215 (8.6%) CVEs over 10-years. WHO/ISH (SEAR B) charts with­ and without-cholesterol predicted 9.3% (235/2517) and 4.2% (106/2517) to be of high CV-risk ≥20%), respectively. Risk predictions of both WHO/ISH (SEAR B) charts with- and without-cholesterol were in agreement in 2033/2517 (80.3%). Risk predictions of WHO/ISH (SEAR B) charts with and with­ out-cholesterol were in agreement with observed CVE percentages among all except in high­ risk females predicted by WHO/ISH (SEAR B) chart with-cholesterol (observed risk 15.3% (95% Cl 12.5 - 18.2%) and predicted risk 2::20%). CONCLUSIONS: WHO/ISH (SEAR B) risk charts provide good 10-year CV-risk predictions for Sri Lankans. The predictions of the two charts, with and without-cholesterol, appear to be in agreement but the chart with-cholesterol seems to be more predictive than the chart without-cholesterol. Risk charts are more predictive in males than in females. The predictive accuracy was best when stratified into two categories; low (<20%) and high (≥20%) risk.
Description: Oral Presentation Abstract (OP12), Ceylon College of Physicians Annual Conference 2020, 19th-21st November. Colombo, Sri Lanka.
ISSN: 2448-9514
Appears in Collections:Conference Papers

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