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DC Field | Value | Language |
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dc.contributor.author | Thulani, U.B. | |
dc.contributor.author | Mettananda, K.C.D. | |
dc.contributor.author | Warnakulasuriya, D.T.D. | |
dc.contributor.author | Peiris, T.S.G. | |
dc.contributor.author | Kasturiratne, K.T.A.A. | |
dc.contributor.author | Ranawaka, U.K. | |
dc.contributor.author | Chackrewarthy, S. | |
dc.contributor.author | Dassanayake, A.S. | |
dc.contributor.author | Kurukulasooriya, S.A.F. | |
dc.contributor.author | Niriella, M.A. | |
dc.contributor.author | de Silva, S.T. | |
dc.contributor.author | Pathmeswaran, A.P. | |
dc.contributor.author | Kato, N. | |
dc.contributor.author | de Silva, H.J. | |
dc.contributor.author | Wickremasinghe, A.R. | |
dc.date.accessioned | 2021-02-12T07:01:19Z | |
dc.date.available | 2021-02-12T07:01:19Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Journal of the Ceylon College of Physicians. 2020; 51(Supplement 1): 12. | en_US |
dc.identifier.issn | 2448-9514 | |
dc.identifier.issn | 0379-802X | |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/21954 | |
dc.description | Oral Presentation Abstract (OP12), Ceylon College of Physicians Annual Conference 2020, 19th-21st November. Colombo, Sri Lanka. | en_US |
dc.description.abstract | INTRODUCTION AND OBJECTIVES: There are no cardiovascular(CV)-risk prediction models specifically for Sri Lankans. Different risk prediction models not validated among Sri Lankans are being used to predict CV-risk of Sri Lankans. We validated the WHO/ISH (SEAR-B) risk prediction charts prospectively in a population-based cohort of Sri Lankans. METHOD: We selected participants between 40-64 years, by stratified random sampling of the Ragama Medical Officer of Health area in 2007 and followed them up for 10-years. Risk predictions for 10-years were calculated using WHO/ISH (SEAR-B) charts with- and without-cholesterol in 2007. We identified all new-onset cardiovascular events(CVE) from 2007-2017 by interviewing participants and perusing medical-records/death-certificates in 2017. We validated the risk predictions against observed CVEs. RESULTS: Baseline cohort consisted of 2517 participants (males 1132 (45%), mean age 53.7 (SD: 6.7 years). We observed 215 (8.6%) CVEs over 10-years. WHO/ISH (SEAR B) charts with and without-cholesterol predicted 9.3% (235/2517) and 4.2% (106/2517) to be of high CV-risk ≥20%), respectively. Risk predictions of both WHO/ISH (SEAR B) charts with- and without-cholesterol were in agreement in 2033/2517 (80.3%). Risk predictions of WHO/ISH (SEAR B) charts with and with out-cholesterol were in agreement with observed CVE percentages among all except in high risk females predicted by WHO/ISH (SEAR B) chart with-cholesterol (observed risk 15.3% (95% Cl 12.5 - 18.2%) and predicted risk 2::20%). CONCLUSIONS: WHO/ISH (SEAR B) risk charts provide good 10-year CV-risk predictions for Sri Lankans. The predictions of the two charts, with and without-cholesterol, appear to be in agreement but the chart with-cholesterol seems to be more predictive than the chart without-cholesterol. Risk charts are more predictive in males than in females. The predictive accuracy was best when stratified into two categories; low (<20%) and high (≥20%) risk. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Ceylon College of Physicians | en_US |
dc.subject | Hypertension | en_US |
dc.title | Validation of the World Health Organization/ International Society of Hypertension (WHO/ISH) cardiovascular risk predictions in Sri Lankans based on findings from a prospective cohort study | en_US |
dc.type | Conference abstract | en_US |
Appears in Collections: | Conference Papers |
Files in This Item:
File | Description | Size | Format | |
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JCCP 5.pdf | 1.58 MB | Adobe PDF | View/Open |
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