Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/21122
Title: High levels of serum angiopoietin 2 and angiopoietin 2/1 ratio at the critical stage of Dengue Hemorrhagic Fever in patients and association with clinical and biochemical parameters
Authors: Mapalagamage, M.
Handunnetti, S.M.
Wickremasinghe, A.R.
Premawansa, G.
Thillainathan, S.
Fernando, T.
Kanapathippillai, K.
de Silva, A.D.
Premawansa, S.
Keywords: Angiopoietin
Issue Date: 2020
Publisher: American Society for Microbiology.
Citation: Journal of Clinical Microbiology. 2020;58(4):e00436-19.
Abstract: ABSTRACT:Longitudinal changes of serum angiopoietin 1 (Ang-1) and angiopoietin 2 (Ang-2) associated with endothelial stability in dengue patients with different disease stages were studied. Serum Ang-1 and Ang-2 levels were measured in confirmed dengue fever (DF) patients on admission (DFA, n = 40) and discharge (DFD, n = 20); in dengue hemorrhagic fever (DHF) patients on admission (DHFA, n = 40), at critical stage (DHFC, n = 36), and on discharge (DHFD, n = 20); and in healthy controls (HC, n = 25). DHFC had the highest serum Ang-2 and lowest Ang-1 levels compared to DFA, DHFA, and HC (P < 0.050). The ratio of serum Ang-2/Ang-1 in DHFC was the highest among all study categories tested (P < 0.001). Significant positive correlations were observed between serum Ang-1 and platelet count in DHFA (Pearson r = 0.653, P < 0.001) and between Ang-1 and pulse pressure in DHFC (r = 0.636, P = 0.001). Using a cutoff value of 1.01 for the Ang-2/Ang-1 ratio for DHFC, a sensitivity of 83.2% and a specificity of 81.2% discerning DF from DHF were obtained. Therefore, serum Ang-2/Ang-1 could be used as a biomarker for endothelial dysfunction in severe dengue at the critical stage. KEYWORDS: angiopoietin; biomarker; dengue fever; dengue hemorrhagic fever; endothelial dysfunction.
Description: Indexed in MEDLINE
URI: http://repository.kln.ac.lk/handle/123456789/21122
ISSN: 0095-1137 (Print)
1098-660X (Electronic)
0095-1137 (Linking)
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