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DC Field | Value | Language |
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dc.contributor.author | Mapalagamage, M. | |
dc.contributor.author | Handunnetti, S.M. | |
dc.contributor.author | Wickremasinghe, A.R. | |
dc.contributor.author | Premawansa, G. | |
dc.contributor.author | Thillainathan, S. | |
dc.contributor.author | Fernando, T. | |
dc.contributor.author | Kanapathippillai, K. | |
dc.contributor.author | de Silva, A.D. | |
dc.contributor.author | Premawansa, S. | |
dc.date.accessioned | 2020-06-15T07:31:16Z | |
dc.date.available | 2020-06-15T07:31:16Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Journal of Clinical Microbiology. 2020;58(4):e00436-19. | en_US |
dc.identifier.issn | 0095-1137 (Print) | |
dc.identifier.issn | 1098-660X (Electronic) | |
dc.identifier.issn | 0095-1137 (Linking) | |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/21122 | |
dc.description | Indexed in MEDLINE | en_US |
dc.description.abstract | ABSTRACT:Longitudinal changes of serum angiopoietin 1 (Ang-1) and angiopoietin 2 (Ang-2) associated with endothelial stability in dengue patients with different disease stages were studied. Serum Ang-1 and Ang-2 levels were measured in confirmed dengue fever (DF) patients on admission (DFA, n = 40) and discharge (DFD, n = 20); in dengue hemorrhagic fever (DHF) patients on admission (DHFA, n = 40), at critical stage (DHFC, n = 36), and on discharge (DHFD, n = 20); and in healthy controls (HC, n = 25). DHFC had the highest serum Ang-2 and lowest Ang-1 levels compared to DFA, DHFA, and HC (P < 0.050). The ratio of serum Ang-2/Ang-1 in DHFC was the highest among all study categories tested (P < 0.001). Significant positive correlations were observed between serum Ang-1 and platelet count in DHFA (Pearson r = 0.653, P < 0.001) and between Ang-1 and pulse pressure in DHFC (r = 0.636, P = 0.001). Using a cutoff value of 1.01 for the Ang-2/Ang-1 ratio for DHFC, a sensitivity of 83.2% and a specificity of 81.2% discerning DF from DHF were obtained. Therefore, serum Ang-2/Ang-1 could be used as a biomarker for endothelial dysfunction in severe dengue at the critical stage. KEYWORDS: angiopoietin; biomarker; dengue fever; dengue hemorrhagic fever; endothelial dysfunction. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | American Society for Microbiology. | en_US |
dc.subject | Angiopoietin | en_US |
dc.title | High levels of serum angiopoietin 2 and angiopoietin 2/1 ratio at the critical stage of Dengue Hemorrhagic Fever in patients and association with clinical and biochemical parameters | en_US |
dc.type | Article | en_US |
Appears in Collections: | Journal/Magazine Articles |
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