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http://repository.kln.ac.lk/handle/123456789/21117
Title: | Comparison of liver MRI R2(FerriScan®) VS liver MRI T2* as a measure of body iron load in a cohort of Beta Thalassaemia major patients |
Authors: | Padeniya, P. Siriwardana, S. Ediriweera, D. Samarasinghe, N. Silva, S. Silva, I. Ahamed, N. Niriella, M.A. Premawardhena, A. |
Keywords: | Liver MRI |
Issue Date: | 2020 |
Publisher: | BioMed Central |
Citation: | Orphanet Journal of Rare Diseases.2020;15(1):26. |
Abstract: | ABSTRACT: To compare the similarity of the non-patented T2* and the high cost patented R2 (Ferriscan®) MRI techniques in the measurement of liver iron concentration (LIC) in heavily transfused patients with thalassaemia major in a real- life Sri Lankan hospital setup. We compared LIC measured by MRI, obtained 2 weeks apart, using both T2* and R2 techniques in 15 patients with beta thalassaemia major. They all had a history of > 100 units of blood transfusions life long and also a history of sub optimal chelation. MRI R2 and MRI T2* scan values showed a negative correlation (co-rrelation coefficient = - 0.63, p = 0.01) This correlation was strong in lower LICs and progressively decreased with upper LIC values. Thus a significant discrepancy was observed between median values of two MRI technologies (p = 0.0005) with T2* tending to underestimate iron overload especially in those with very high LIC identified by R2. The lack of concordance of T2* and R2 especially in those with very high reading on R2 suggest the potential errors in interpretations that can occur in "non-expert centres"; which are likely to lead to errors in clinical judgement on the intensity of chelation therapy needed. KEYWORDS: FerriScan®; Iron overload; Liver iron concentration; MRI; T2* scan. |
Description: | Indexed in MEDLINE, SCOPUS, SCIE |
URI: | http://repository.kln.ac.lk/handle/123456789/21117 |
ISSN: | 1750-1172 (Electronic) 1750-1172 (Linking) |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
File | Description | Size | Format | |
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Comparison of liver MRI R2.pdf | 689.6 kB | Adobe PDF | View/Open |
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