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DC Field | Value | Language |
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dc.contributor.author | Padeniya, P. | |
dc.contributor.author | Siriwardana, S. | |
dc.contributor.author | Ediriweera, D. | |
dc.contributor.author | Samarasinghe, N. | |
dc.contributor.author | Silva, S. | |
dc.contributor.author | Silva, I. | |
dc.contributor.author | Ahamed, N. | |
dc.contributor.author | Niriella, M.A. | |
dc.contributor.author | Premawardhena, A. | |
dc.date.accessioned | 2020-06-15T06:09:17Z | |
dc.date.available | 2020-06-15T06:09:17Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Orphanet Journal of Rare Diseases.2020;15(1):26. | en_US |
dc.identifier.issn | 1750-1172 (Electronic) | |
dc.identifier.issn | 1750-1172 (Linking) | |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/21117 | |
dc.description | Indexed in MEDLINE, SCOPUS, SCIE | en_US |
dc.description.abstract | ABSTRACT: To compare the similarity of the non-patented T2* and the high cost patented R2 (Ferriscan®) MRI techniques in the measurement of liver iron concentration (LIC) in heavily transfused patients with thalassaemia major in a real- life Sri Lankan hospital setup. We compared LIC measured by MRI, obtained 2 weeks apart, using both T2* and R2 techniques in 15 patients with beta thalassaemia major. They all had a history of > 100 units of blood transfusions life long and also a history of sub optimal chelation. MRI R2 and MRI T2* scan values showed a negative correlation (co-rrelation coefficient = - 0.63, p = 0.01) This correlation was strong in lower LICs and progressively decreased with upper LIC values. Thus a significant discrepancy was observed between median values of two MRI technologies (p = 0.0005) with T2* tending to underestimate iron overload especially in those with very high LIC identified by R2. The lack of concordance of T2* and R2 especially in those with very high reading on R2 suggest the potential errors in interpretations that can occur in "non-expert centres"; which are likely to lead to errors in clinical judgement on the intensity of chelation therapy needed. KEYWORDS: FerriScan®; Iron overload; Liver iron concentration; MRI; T2* scan. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | BioMed Central | en_US |
dc.subject | Liver MRI | en_US |
dc.title | Comparison of liver MRI R2(FerriScan®) VS liver MRI T2* as a measure of body iron load in a cohort of Beta Thalassaemia major patients | en_US |
dc.type | Article | en_US |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
File | Description | Size | Format | |
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Comparison of liver MRI R2.pdf | 689.6 kB | Adobe PDF | View/Open |
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