Please use this identifier to cite or link to this item:
http://repository.kln.ac.lk/handle/123456789/20273
Title: | Predictive value of persistent NS1 antigen positivity beyond 3rd day for dengue haemorrhagic fever in Sri Lankan children. |
Authors: | Manamperi, M. Jayamanne, B. D. W. Somaratne, T. Perera, N. Fernando, L. |
Keywords: | DHF prediction |
Issue Date: | 2019 |
Publisher: | London : Biomed Central |
Citation: | BMC Research Notes.2019;12(1):214 |
Abstract: | OBJECTIVE:Dengue haemorrhagic fever (DHF) is a major public health concern responsible for significant morbidity in both adult and paediatric populations in Sri Lanka. This study examined if persistent non structural protein 1 (NS1) antigen positivity beyond day 3 was predictive of the occurrence of dengue haemorrhagic fever. The patients were followed up during their in-hospital stay and the severity of the illness was classified according to the WHO classification. The NS1 antigen test was repeated after day 3 of the onset of illness, at least 2 days after the initial test. RESULTS: One hundred and fifty-seven patients were enrolled. Persistent NS1 antigen test positivity after day 3 of the illness was not predictive of subsequent development of DHF. Out of multiple other demographic and illness related factors assessed, only having a secondary dengue infection was associated with a high risk of DHF (relative risk = 3.077, 95% CI 1.361, 6.954). Persistent NS1 positivity on day 3 may not be indicative of disease severity. However results need to be confirmed by a larger study with quantitative NS1 testing. |
Description: | indexed in MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/20273 |
ISSN: | 1756-0500 (Electronic) |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Dengue.pdf | 603.25 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.