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http://repository.kln.ac.lk/handle/123456789/19267
Title: | The Association between new generation oral contraceptive pill and the development of inflammatory bowel diseases |
Authors: | Sanagapalli, S. Ko, Y. Kariyawasam, V. Ng, S.C. Tang, W. de Silva, H.J. Chen, M. Wu, K. Aniwan, S. Ng, K.K. Ong, D. Ouyang, Q. Hilmi, I. Simadibrata, M. Pisespongsa, P. Gopikrishna, S. Leong, R.W. IBD Sydney Organization and the asia-Pacific Crohn's Epidemiology Study (ACCESS) Group |
Keywords: | Inflammatory Bowel Diseases Contraceptive Agents Contraceptive Agents, Hormonal Contraceptives, Oral Contraceptives, Oral-adverse effects |
Issue Date: | 2018 |
Publisher: | Korean Association for the Study of Intestinal Diseases |
Citation: | Intestinal Research. 2018;16(3): 409-415 |
Abstract: | BACKGROUND/AIMS: To examine the association between use of oral contraceptive pills (OCPs) and the risk of developing inflammatory bowel diseases (IBD), in a modern cohort. METHODS: A prospective nested case-control study across sites in the Asia-Pacific region was conducted; involving female IBD cases and asymptomatic controls. Subjects completed a questionnaire addressing questions related to OCP use. Primary outcome was the risk of development of IBD of those exposed to OCP versus non-exposure. Secondary outcomes were development of Crohn's disease (CD) versus ulcerative colitis (UC), and whether age of first use of OCP use may be associated with risk of IBD. RESULTS: Three hundred and forty-eight female IBD cases (41% CD, median age: 43 years) and 590 female age-matched controls were recruited. No significant association was found between OCP use and the risk of IBD (odds ratio [OR], 1.65; 95% confidence interval, 0.77-3.13; P=0.22), CD (OR, 1.55) or UC (OR, 1.01). The lack of association persisted when results were adjusted for age and smoking. IBD cases commenced OCP use at a younger age than controls (18 years vs. 20 years, P=0.049). CONCLUSIONS: In this large cohort of subjects from the Asia-Pacific region, we found a modest but not significantly increased risk of developing IBD amongst OCP users. |
Description: | Indexed in Scopus; In PUBMED; Indexed in MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/19267 |
ISSN: | 2288-1956 (Electronic) 1598-9100 (Print) 1598-9100 (Linking) |
Appears in Collections: | Journal/Magazine Articles |
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ir-16-409.pdf | 652.96 kB | Adobe PDF | View/Open |
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