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http://repository.kln.ac.lk/handle/123456789/19050
Title: | Is Total Serum Nitrite and Nitrate (NOx) Level in Dengue Patients a Potential Prognostic Marker of Dengue Hemorrhagic Fever? |
Authors: | Mapalagamage, M. Handunnetti, S. Premawansa, G. Thillainathan, S. Fernando, T. Kanapathippillai, K. Wickremasinghe, R. de Silva, A.D. Premawansa, S. |
Keywords: | Dengue |
Issue Date: | 2018 |
Publisher: | Hindawi Pub. Corp. |
Citation: | Disease Markers. 2018 : 5328681 |
Abstract: | Potential use of total nitrite plus nitrate (NOx) and nitrite (NO2-) separately as surrogate markers for serum nitric oxide in severe dengue and their longitudinal changes along with the progression of infection was studied. Deproteinized sera from confirmed dengue fever (DF, n = 145) and dengue hemorrhagic fever (DHF, n = 74) patients on admission-A, critical-C, discharge-D, and convalescence-CON stages and from age-gender matched healthy individuals (HC, n = 77) were taken to assess NO2- and NOx levels using Griess and modified Griess assays. Serum NOx in DHFA was significantly lower compared to DFA (p < 0.001). HC had the lowest NOx and NO2- compared to all patient categories (p < 0.001) except NO2- in DF-CON and DHF-CON and NOx in DHF-CON. Serum NOx and NO2- in DHF patients admitted on fever day 3 (DHFA-3) was significantly lower compared to DFA-3 (p < 0.05). Cut-off values of 4.46 μM for NOx (91.3% sensitivity and 80.1% specificity) and 1.25 μM for NO2-(75.0% sensitivity and 73.3% specificity) were obtained for day 3 of fever. Serum NOx may be used as potential prognostic marker of DHF in patients presenting with DF in the early stage (on day 3 of fever) of the disease. |
Description: | Indexed In MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/19050 |
ISSN: | 0278-0240 (Print) 1875-8630 (Electronic) 0278-0240 (Linking) |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
File | Description | Size | Format | |
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DM2018-5328681.pdf | 1.01 MB | Adobe PDF | View/Open |
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