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DC Field | Value | Language |
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dc.contributor.author | Mapalagamage, M. | en |
dc.contributor.author | Handunnetti, S. | en |
dc.contributor.author | Premawansa, G. | en |
dc.contributor.author | Thillainathan, S. | en_US |
dc.contributor.author | Fernando, T. | en |
dc.contributor.author | Kanapathippillai, K. | en |
dc.contributor.author | Wickremasinghe, R. | en |
dc.contributor.author | de Silva, A.D. | en_US |
dc.contributor.author | Premawansa, S. | en_US |
dc.date.accessioned | 2018-09-26T05:48:51Z | en_US |
dc.date.available | 2018-09-26T05:48:51Z | en |
dc.date.issued | 2018 | en_US |
dc.identifier.citation | Disease Markers. 2018 : 5328681 | en_US |
dc.identifier.issn | 0278-0240 (Print) | |
dc.identifier.issn | 1875-8630 (Electronic) | |
dc.identifier.issn | 0278-0240 (Linking) | |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/19050 | |
dc.description | Indexed In MEDLINE | en_US |
dc.description.abstract | Potential use of total nitrite plus nitrate (NOx) and nitrite (NO2-) separately as surrogate markers for serum nitric oxide in severe dengue and their longitudinal changes along with the progression of infection was studied. Deproteinized sera from confirmed dengue fever (DF, n = 145) and dengue hemorrhagic fever (DHF, n = 74) patients on admission-A, critical-C, discharge-D, and convalescence-CON stages and from age-gender matched healthy individuals (HC, n = 77) were taken to assess NO2- and NOx levels using Griess and modified Griess assays. Serum NOx in DHFA was significantly lower compared to DFA (p < 0.001). HC had the lowest NOx and NO2- compared to all patient categories (p < 0.001) except NO2- in DF-CON and DHF-CON and NOx in DHF-CON. Serum NOx and NO2- in DHF patients admitted on fever day 3 (DHFA-3) was significantly lower compared to DFA-3 (p < 0.05). Cut-off values of 4.46 μM for NOx (91.3% sensitivity and 80.1% specificity) and 1.25 μM for NO2-(75.0% sensitivity and 73.3% specificity) were obtained for day 3 of fever. Serum NOx may be used as potential prognostic marker of DHF in patients presenting with DF in the early stage (on day 3 of fever) of the disease. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Hindawi Pub. Corp. | en_US |
dc.subject | Dengue | en_US |
dc.title | Is Total Serum Nitrite and Nitrate (NOx) Level in Dengue Patients a Potential Prognostic Marker of Dengue Hemorrhagic Fever? | en_US |
dc.type | Article | en_US |
Appears in Collections: | Journal/Magazine Articles |
Files in This Item:
File | Description | Size | Format | |
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DM2018-5328681.pdf | 1.01 MB | Adobe PDF | View/Open |
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