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Title: Human infection with Wuchereria bancrofti in Matara, Sri Lanka: the use, in parallel, of an ELISA to detect filaria-specific IgG4 in urine and of ICT card tests to detect filarial antigen in whole blood
Authors: Weerasooriya, M.V.
Itoh, M.
Mudalige, M.P.
Qiu, X.G.
Kimura, E.
Gunawardena, N.K.
Fujimaki, Y.
Keywords: Filariasis
Wuchereria bancrofti-immunology
Enzyme-Linked Immunosorbent Assay-methods
Antigens, Helminth-blood
Sri Lanka-epidemiology
Immunoglobulin G-analysis
Issue Date: 2003
Publisher: Academic Press
Citation: Annals of Tropical Medicine and Parasitology. 2003; 97(2): pp.179-85
Abstract: The ICT card test to detect circulating filarial antigen and an ELISA that detects filaria-specific urinary IgG(4) were each used to screen 473 subjects from a community in Sri Lanka where Wuchereria bancrofti is endemic. When the ICT test was used as the gold standard, the ELISA was found to have a sensitivity of 91.2%. However, far more of the subjects were found ELISA-positive than ICT-positive (76.5% v. 31.1%). The youngest children studied (aged 1-10 years) were similar to the adult subjects in terms of the prevalence of antigenaemia (33.8%) and the prevalence (72.1%) and concentration of filaria-specific IgG(4) in their urine. Therefore, especially as urine samples are easier, less painful and safer to collect than blood samples, the ELISA may be particularly useful to screen very young and school-age children, to estimate current levels of transmission in a particular area.
Description: Indexed in MEDLINE
ISSN: 0003-4983 (Print)
1364-8594 (Electronic)
Appears in Collections:Journal/Magazine Articles

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