Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/1498
Title: The Molecular classification of the clinical manifestations of Crohn's Disease.
Authors: Ahamad, T.
Armuzzi, A.
Bunce, M.
Mulcahy-Hawes, K.
Marshall, S.E.
Orchard, T.R.
Crawshaw, J.
Large, O.
de Silva, A.
Cook, J.T.
Barnardo, M.
Cullen, S.
Welsh, K.I.
Jewell, D.P.
Keywords: Crohn Disease
Crohn Disease-classification
Crohn Disease-mortality
Crohn Disease-genetics
Intracellular Signaling Peptides and Proteins
Issue Date: 2002
Publisher: Elsevier-W.B. Saunders
Citation: Gastroenterology. 2002; 122(4): pp.854-66
Abstract: BACKGROUND & AIMS: Crohn's disease is a common inflammatory disorder of the gut characterized by variation in both location and behavior. Chromosome 16 and the HLA region on chromosome 6 have been implicated in susceptibility to disease. Mutations in the NOD2/CARD15 gene, recently identified on chromosome 16, have been associated with disease overall but are found in only 25% of patients. No data regarding their contribution to specific disease subtypes exist. Here we report a detailed genotype-phenotype analysis of 244 accurately characterized patients. METHODS: A total of 244 white patients with Crohn's disease recruited from a single center in the United Kingdom were studied. All patients were rigorously phenotyped and followed-up for a median time of 16 years. By using linkage disequilibrium mapping we studied 340 polymorphisms in 24 HLA genes and 3 NOD2/CARD15 polymorphisms. RESULTS: We show that NOD2/CARD15 mutations determine ileal disease only. We confirm that alleles on specific long-range HLA haplotypes determine overall susceptibility and describe novel genetic associations with susceptibility, location, and behavior of Crohn's disease. CONCLUSIONS: The clinical pattern of Crohn's disease may be defined by specific genotypes. This study may provide the basis for a future molecular classification of disease.
Description: Indexed in MEDLINE
URI: http://repository.kln.ac.lk/handle/123456789/1498
ISSN: 0016-5085 (Print)
1528-0012 (Electronic)
Appears in Collections:Journal/Magazine Articles

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