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DC Field | Value | Language |
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dc.contributor.author | Ahamad, T. | en_US |
dc.contributor.author | Armuzzi, A. | en_US |
dc.contributor.author | Bunce, M. | en_US |
dc.contributor.author | Mulcahy-Hawes, K. | en_US |
dc.contributor.author | Marshall, S.E. | en_US |
dc.contributor.author | Orchard, T.R. | en_US |
dc.contributor.author | Crawshaw, J. | en_US |
dc.contributor.author | Large, O. | en_US |
dc.contributor.author | de Silva, A. | en_US |
dc.contributor.author | Cook, J.T. | en_US |
dc.contributor.author | Barnardo, M. | en_US |
dc.contributor.author | Cullen, S. | en_US |
dc.contributor.author | Welsh, K.I. | en_US |
dc.contributor.author | Jewell, D.P. | en_US |
dc.date.accessioned | 2014-10-29T09:19:25Z | - |
dc.date.available | 2014-10-29T09:19:25Z | - |
dc.date.issued | 2002 | en_US |
dc.identifier.citation | Gastroenterology. 2002; 122(4): pp.854-66 | en_US |
dc.identifier.issn | 0016-5085 (Print) | en_US |
dc.identifier.issn | 1528-0012 (Electronic) | en_US |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/1498 | - |
dc.description | Indexed in MEDLINE | - |
dc.description.abstract | BACKGROUND & AIMS: Crohn's disease is a common inflammatory disorder of the gut characterized by variation in both location and behavior. Chromosome 16 and the HLA region on chromosome 6 have been implicated in susceptibility to disease. Mutations in the NOD2/CARD15 gene, recently identified on chromosome 16, have been associated with disease overall but are found in only 25% of patients. No data regarding their contribution to specific disease subtypes exist. Here we report a detailed genotype-phenotype analysis of 244 accurately characterized patients. METHODS: A total of 244 white patients with Crohn's disease recruited from a single center in the United Kingdom were studied. All patients were rigorously phenotyped and followed-up for a median time of 16 years. By using linkage disequilibrium mapping we studied 340 polymorphisms in 24 HLA genes and 3 NOD2/CARD15 polymorphisms. RESULTS: We show that NOD2/CARD15 mutations determine ileal disease only. We confirm that alleles on specific long-range HLA haplotypes determine overall susceptibility and describe novel genetic associations with susceptibility, location, and behavior of Crohn's disease. CONCLUSIONS: The clinical pattern of Crohn's disease may be defined by specific genotypes. This study may provide the basis for a future molecular classification of disease. | en_US |
dc.publisher | Elsevier-W.B. Saunders | en_US |
dc.subject | Crohn Disease | - |
dc.subject | Crohn Disease-classification | - |
dc.subject | Crohn Disease-mortality | - |
dc.subject | Crohn Disease-genetics | - |
dc.subject | Intracellular Signaling Peptides and Proteins | - |
dc.title | The Molecular classification of the clinical manifestations of Crohn's Disease. | en_US |
dc.type | Article | en_US |
dc.identifier.department | Medicine | en_US |
dc.creator.corporateauthor | American Gastroenterological Association | en_US |
dc.description.note | Erratum in Gastroenterology 2003. 125(1): 281 | en_US |
Appears in Collections: | Journal/Magazine Articles |
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