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Title: | Genetic determinants of jaundice and gallstones in haemoglobin E beta thalassaemia |
Authors: | Premawardhena, A.P. Fisher, C.A. Fathihu, F. de Silva, S. Perera, W. Peto, T.E. Olivieri, N.F. Weatherall, D.J. |
Issue Date: | 2001 |
Citation: | Lancet.2001; 357(9272): 1945-46 |
Abstract: | Chronic hyperbilirubinaemia, gallstone formation, and gall bladder disease are unusually common in people with haemoglobin E beta thalassaemia in Sri Lanka. To determine whether this has a genetic basis we compared the bilirubin levels and frequency of gallstones in patients with different alleles of the UGT*1 gene. There was a significantly higher bilirubin level in those with the 7/7 genotypes compared with 6/6 and 6/7 genotype (p=0.032 and 0.0015 respectively), who also appeared more prone to gallstone formation. These results suggest that the UGT*1 genotpe is of importance in the genesis of gallstones in this population of patients. |
URI: | http://repository.kln.ac.lk/handle/123456789/1484 |
ISSN: | Lancet Publishing Group |
Appears in Collections: | Journal/Magazine Articles |
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