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Please use this identifier to cite or link to this item: http://repository.kln.ac.lk/handle/123456789/1484
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dc.contributor.authorPremawardhena, A.P.en_US
dc.contributor.authorFisher, C.A.en_US
dc.contributor.authorFathihu, F.en_US
dc.contributor.authorde Silva, S.en_US
dc.contributor.authorPerera, W.en_US
dc.contributor.authorPeto, T.E.en_US
dc.contributor.authorOlivieri, N.F.en_US
dc.contributor.authorWeatherall, D.J.en_US
dc.date.accessioned2014-10-29T09:19:17Z
dc.date.available2014-10-29T09:19:17Z
dc.date.issued2001en_US
dc.identifier.citationLancet.2001; 357(9272): 1945-46en_US
dc.identifier.issnLancet Publishing Groupen_US
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/1484
dc.description.abstractChronic hyperbilirubinaemia, gallstone formation, and gall bladder disease are unusually common in people with haemoglobin E beta thalassaemia in Sri Lanka. To determine whether this has a genetic basis we compared the bilirubin levels and frequency of gallstones in patients with different alleles of the UGT*1 gene. There was a significantly higher bilirubin level in those with the 7/7 genotypes compared with 6/6 and 6/7 genotype (p=0.032 and 0.0015 respectively), who also appeared more prone to gallstone formation. These results suggest that the UGT*1 genotpe is of importance in the genesis of gallstones in this population of patients.
dc.titleGenetic determinants of jaundice and gallstones in haemoglobin E beta thalassaemiaen_US
dc.typeArticleen_US
dc.identifier.departmentMedicineen_US
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