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Title: | Abnormal functions of pottasium channels in the platelets of patients with Alzheimer's disease |
Authors: | de Silva, H.A. Aronson, J.K. Grahame-Smith, D.G. Jobst, K.A. Smith, A.D. |
Keywords: | Alzheimer Disease Alzheimer Disease-blood Elapid Venoms-pharmacology Charybdotoxin-pharmacology Apamin-pharmacology Potassium Channel Blockers Potassium Channels-metabolism Rubidium-metabolism Comparative Study |
Issue Date: | 1998 |
Publisher: | Lancet Publishing Group |
Citation: | Lancet. 1998; 352: pp.1590-1593 |
Abstract: | BACKGROUND:Reports of abnormalities of potassium-channel function in various cultured cells of Alzheimer's disease patients led us to attempt to characterise the pharmacological characteristics of the abnormal channel.METHODS: We studied platelets from 14 patients with Alzheimer-type dementia and 14 non-demented controls matched for age and sex. The effects of specific inhibitors of K+ channels on the efflux of rubidium-86 ions, a radioactive analogue of K+, from the platelets were measured.FINDINGS: Normal platelets contain three types of K+ channel, sensitive to the inhibitory actions of apamin (small-conductance calcium-dependent potassium channels), charybdotoxin (of less specificity, but probably intermediate-conductance calcium-dependent K+ channels), and alpha-dendrotoxin (voltage-sensitive K+ channels). However, 8Rb+ efflux from the platelets of patients with Alzheimer-type dementia was not inhibited by either apamin or charybdotoxin. By contrast, inhibition by alpha-dendrotoxin did occur. INTERPRETATION: Our results suggest that calcium-dependent K+ channels in platelets are selectively impaired in Alzheimer's disease. A similar abnormality in neurons could contribute to the pathophysiology of the disorder. |
Description: | Indexed in MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/1342 |
ISSN: | 0140-6736 (Print) 1474-547X (Electronic) |
Appears in Collections: | Journal/Magazine Articles |
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