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DC Field | Value | Language |
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dc.contributor.author | de Silva, H.A. | en_US |
dc.contributor.author | Aronson, J.K. | en_US |
dc.contributor.author | Grahame-Smith, D.G. | en_US |
dc.contributor.author | Jobst, K.A. | en_US |
dc.contributor.author | Smith, A.D. | en_US |
dc.date.accessioned | 2014-10-29T09:15:29Z | |
dc.date.available | 2014-10-29T09:15:29Z | |
dc.date.issued | 1998 | en_US |
dc.identifier.citation | Lancet. 1998; 352: pp.1590-1593 | en_US |
dc.identifier.issn | 0140-6736 (Print) | en_US |
dc.identifier.issn | 1474-547X (Electronic) | en_US |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/1342 | |
dc.description | Indexed in MEDLINE | |
dc.description.abstract | BACKGROUND:Reports of abnormalities of potassium-channel function in various cultured cells of Alzheimer's disease patients led us to attempt to characterise the pharmacological characteristics of the abnormal channel.METHODS: We studied platelets from 14 patients with Alzheimer-type dementia and 14 non-demented controls matched for age and sex. The effects of specific inhibitors of K+ channels on the efflux of rubidium-86 ions, a radioactive analogue of K+, from the platelets were measured.FINDINGS: Normal platelets contain three types of K+ channel, sensitive to the inhibitory actions of apamin (small-conductance calcium-dependent potassium channels), charybdotoxin (of less specificity, but probably intermediate-conductance calcium-dependent K+ channels), and alpha-dendrotoxin (voltage-sensitive K+ channels). However, 8Rb+ efflux from the platelets of patients with Alzheimer-type dementia was not inhibited by either apamin or charybdotoxin. By contrast, inhibition by alpha-dendrotoxin did occur. INTERPRETATION: Our results suggest that calcium-dependent K+ channels in platelets are selectively impaired in Alzheimer's disease. A similar abnormality in neurons could contribute to the pathophysiology of the disorder. | en_US |
dc.publisher | Lancet Publishing Group | en_US |
dc.subject | Alzheimer Disease | en_US |
dc.subject | Alzheimer Disease-blood | en_US |
dc.subject | Elapid Venoms-pharmacology | en_US |
dc.subject | Charybdotoxin-pharmacology | en_US |
dc.subject | Apamin-pharmacology | en_US |
dc.subject | Potassium Channel Blockers | en_US |
dc.subject | Potassium Channels-metabolism | en_US |
dc.subject | Rubidium-metabolism | en_US |
dc.subject | Comparative Study | en_US |
dc.title | Abnormal functions of pottasium channels in the platelets of patients with Alzheimer's disease | en_US |
dc.type | Article | en_US |
dc.identifier.department | Pharmacology | en_US |
Appears in Collections: | Journal/Magazine Articles |
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