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Title: | Serological diagnosis of infection by Shigella dysenteriae-1 in patients with bacillary dysentery. |
Authors: | de Silva, D.G.H. Candy, D.C. Mendis, L.N. Chart, H. Rowe, B. |
Keywords: | Shigella dysenteriae Shigella dysenteriae-classification Dysentery, Bacillary-diagnosis Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay Escherichia coli-isolation and purification Immunoglobulin M-immunology Lipopolysaccharides-immunology |
Issue Date: | 1992 |
Publisher: | Elsevier-W.B. Saunders |
Citation: | The Journal of Infection. 1992; 25(3): pp.273-278 |
Abstract: | A total of 192 samples of serum from 113 Sri Lankan patients with clinical dysentery was examined for antibodies of the IgM class to the lipopolysaccharides (LPSs) of Shigella dysenteriae-1 and Escherichia coli O157:H7. By means of ELISA and immunoblotting, 59 patients were found to have serum antibodies to the LPS of S. dysenteriae-1 only. Four samples from one patient were found to contain serum antibodies to the LPSs of both S. dysenteriae-1 and E. coli O157:H7. Antibodies to the LPS of S. dysenteriae-1 were also detected in 16 samples from 25 children, from Sri Lanka, with no previous history of dysentery; one of these children also had antibodies to the LPS of E. coli O157:H7. Analysis of 16 samples from apparently healthy children in the U.K. showed that only one serum contained antibodies to the LPS of S. dysenteriae-1. This patient had a history of recent travel to Pakistan. The isolation of S. dysenteriae-1 remains the preferred test for the diagnosis of bacillary dysentery. The use of serology as a means of providing evidence of infection with S. dysenteriae-1, however may prove to be a useful adjunct to cultural techniques but needs to be validated in an area where this organism is endemic |
Description: | Indexed in MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/1167 |
ISSN: | 0163-4453 (Print) 1532-2742 (Electronic) |
Appears in Collections: | Journal/Magazine Articles |
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