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Title: | Drug induced alterations in some rat hepatic microsomal components:a comparative study of four structurally different antimalarials |
Authors: | Thabrew, M.I. Nashiru, T.O. Emerole, G.O. |
Keywords: | Antimalarials-pharmacology |
Issue Date: | 1985 |
Publisher: | Pergamon Press |
Citation: | Comparative Biochemistry and Physiology.C. 1985; 81(1): pp.133-138 |
Abstract: | Alterations in microsomal drug metabolizing enzymes, microsomal lipids and some serum enzymes following pre-treatment of rats with therapeutic doses of four structurally different antimalarial compounds, chloroquine (CQ), quinine (Q), quinacrine (QK) and primaquine (PQ) have been investigated. CQ and Q significantly decreased the activities of aminopyrene N-demethylase, aniline hydroxylase and both microsomal and cytosolic glutathione S-transferases. Only aniline hydroxylase was markedly decreased by QK, while PQ did not have much effect on any of these enzymes. CQ, Q and QK significantly increased the cholesterol:phospholipid ratio while all four compounds decreased the phosphatidyl choline:sphingomyelin (PC/S) ratio. All the drugs increased the activities of the serum enzymes glutamate-oxaloacetate transaminase, glutamate-pyruvate transaminase and alkaline phosphatase. The possible relationships of these results to structural variations in the four drugs being investigated has been discussed |
Description: | Indexed in MEDLINE |
URI: | http://repository.kln.ac.lk/handle/123456789/1106 |
ISSN: | 0742-8413 (Print) |
Appears in Collections: | Journal/Magazine Articles |
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