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DC Field | Value | Language |
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dc.contributor.author | Thabrew, M.I. | en_US |
dc.contributor.author | Nashiru, T.O. | en_US |
dc.contributor.author | Emerole, G.O. | en_US |
dc.date.accessioned | 2014-10-29T09:09:53Z | - |
dc.date.available | 2014-10-29T09:09:53Z | - |
dc.date.issued | 1985 | en_US |
dc.identifier.citation | Comparative Biochemistry and Physiology.C. 1985; 81(1): pp.133-138 | en_US |
dc.identifier.issn | 0742-8413 (Print) | en_US |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/1106 | - |
dc.description | Indexed in MEDLINE | - |
dc.description.abstract | Alterations in microsomal drug metabolizing enzymes, microsomal lipids and some serum enzymes following pre-treatment of rats with therapeutic doses of four structurally different antimalarial compounds, chloroquine (CQ), quinine (Q), quinacrine (QK) and primaquine (PQ) have been investigated. CQ and Q significantly decreased the activities of aminopyrene N-demethylase, aniline hydroxylase and both microsomal and cytosolic glutathione S-transferases. Only aniline hydroxylase was markedly decreased by QK, while PQ did not have much effect on any of these enzymes. CQ, Q and QK significantly increased the cholesterol:phospholipid ratio while all four compounds decreased the phosphatidyl choline:sphingomyelin (PC/S) ratio. All the drugs increased the activities of the serum enzymes glutamate-oxaloacetate transaminase, glutamate-pyruvate transaminase and alkaline phosphatase. The possible relationships of these results to structural variations in the four drugs being investigated has been discussed | en_US |
dc.publisher | Pergamon Press | en_US |
dc.subject | Antimalarials-pharmacology | - |
dc.title | Drug induced alterations in some rat hepatic microsomal components:a comparative study of four structurally different antimalarials | en_US |
dc.type | Article | en_US |
dc.identifier.department | Biochemistry | en_US |
Appears in Collections: | Journal/Magazine Articles |
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