The Concept of Metal-Drug Synergism in the Search for Novel Chloroquine Derived Antimalarial Drugs

Abstract

Malaria is widespread in many tropical and subtropical regions and it kills more people than any other communicable disease except for tuberculosis. According to the World Health Organization, 300-500 million people become infected and close to a million die of malaria each year, mostly children under 5 years of age. About 40% of the world?s population is at risk of contracting malaria, particularly in the poorest 1 countries. It is believed that malaria originated in West and Central Africa and spread all across the globe to become the worst killer disease.