Effect of Melothria maderaspatana on carbon tetrachloride-induced changes in rat hepatic microsomal drug-metabolizing enzyme activity

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dc.contributor.authorJayathilake, K.A.en_US
dc.contributor.authorThabrew, M.I.en_US
dc.contributor.authorPerera, D.J.en_US
dc.creator.corporateauthorInternational Society for Ethnopharmacologyen_US
dc.date.accessioned2014-10-29T09:10:08Z
dc.date.available2014-10-29T09:10:08Z
dc.date.issued1990en_US
dc.descriptionIndexed in MEDLINE
dc.description.abstractTreatment with an aqueous extract of the aerial parts of Melothria maderaspatana, before or after CCl4 administration in rats markedly decreased CCl4-mediated reductions in aniline hydroxylase and p-aminopyrine N-demethylase activities. Phenobarbital-induced sleeping time in rats and kinetic enzyme studies showed that the effect of the plant was neither due to an induction of the drug metabolizing enzymes nor due to an alteration in the Km values of the enzymes.
dc.identifier.citationJournal of Ethnopharmacology. 1990; 30(1): pp.97-105en_US
dc.identifier.departmentBiochemistryen_US
dc.identifier.issn0378-8741 (Print)en_US
dc.identifier.issn1872-7573 (Electronic)en_US
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/1133
dc.publisherElsevieren_US
dc.subjectPlant Extracts
dc.subjectPlant Extracts-pharmacology
dc.subjectPharmaceutical Preparations-metabolism-
dc.subjectCarbon Tetrachloride-toxicity
dc.subjectLipid Peroxidation/drug effects
dc.subjectMicrosomes, Liver-enzymology
dc.subjectMixed Function Oxygenases-metabolism
dc.titleEffect of Melothria maderaspatana on carbon tetrachloride-induced changes in rat hepatic microsomal drug-metabolizing enzyme activityen_US
dc.typeArticleen_US

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