Effect of Melothria maderaspatana on carbon tetrachloride-induced changes in rat hepatic microsomal drug-metabolizing enzyme activity
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Date
1990
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Treatment with an aqueous extract of the aerial parts of Melothria maderaspatana, before or after CCl4 administration in rats markedly decreased CCl4-mediated reductions in aniline hydroxylase and p-aminopyrine N-demethylase activities. Phenobarbital-induced sleeping time in rats and kinetic enzyme studies showed that the effect of the plant was neither due to an induction of the drug metabolizing enzymes nor due to an alteration in the Km values of the enzymes.
Description
Indexed in MEDLINE
Keywords
Plant Extracts, Plant Extracts-pharmacology, Pharmaceutical Preparations-metabolism-, Carbon Tetrachloride-toxicity, Lipid Peroxidation/drug effects, Microsomes, Liver-enzymology, Mixed Function Oxygenases-metabolism
Citation
Journal of Ethnopharmacology. 1990; 30(1): pp.97-105