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The aetiology of chronic clinical or biochemical hepatic dysfunction in a group of adult Sri Lankans: experience in a tertiary referral centre

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dc.contributor.author Satarasinghe, R.L.
dc.contributor.author de Silva, A.P.
dc.contributor.author Arulnity, K.
dc.date.accessioned 2015-10-06T03:38:44Z
dc.date.available 2015-10-06T03:38:44Z
dc.date.issued 2005
dc.identifier.citation The Ceylon Medical Journal. 2005; 50(Supplement 1):46 en_US
dc.identifier.issn 0009-0875 (Print)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/9943
dc.description Poster Presentation Abstract (PP19), 118th Annual Scientific Sessions, Sri Lanka Medical Association, 2005 Colombo, Sri Lanka en_US
dc.description.abstract OBJECTIVES: To evaluate the histological outcome and clinical implications of such a finding in a group of adults who were admitted for investigation of either clinical or biochemical hepatic dysfunction lasting over 3 months. DESIGN AND SETTING: 100 consecutive liver biopsies performed from 15.2.2002 to 30.9.2004 in patients with abnormal hepatic function for at least three months prior to biopsy were reviewed. The clinicopathological features of patients who showed histological evidence of chronic liver disease were analysed retrospectively by examining their case notes. RESULTS: The age range was 15 - 80 years. Male to Female ratio 2.5:1. The peek incidence (37%) of chronic liver damage was seen in 40-49 year group, while 57% was within 50-59 year group. Histology showed cirrhosis, non-alcoholic steatohepatitis (NASH), steatosis, hepatoma, and chronic active hepatitis in 54%, 14%, 8%, 5%, and 4% respectively. There was a high male preponderance for NASH (M: F=8: l) and cirrhosis (M: F=6: l). 57% of cirrhotics were alcoholics. Hepatitis C serology was negative in all, and only one was positive for hepatitis B serology. 33% of patients with NASH had Diabetes mellitus and another 33% of patients with NASH had dyslipidaemias. Diet, social class and obesity were not associated with NASH. CONCLUSIONS: NASH and hepatic steatosis are emerging as significant causes for chronic hepatic dysfunction. The aetiology of non-alcoholic cirrhosis merit in depth study. en_US
dc.language.iso en_US en_US
dc.publisher Sri Lanka Medical Association en_US
dc.subject biochemical hepatic dysfunction en_US
dc.title The aetiology of chronic clinical or biochemical hepatic dysfunction in a group of adult Sri Lankans: experience in a tertiary referral centre en_US
dc.type Article en_US


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