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Reappraisal of symptoms and signs of uncomplicated β thalassemia trait

Show simple item record Premawardhena, A. Malewana, T. Weerasinghe, M. Arambepola, M. 2015-10-05T07:14:23Z 2015-10-05T07:14:23Z 2005
dc.identifier.citation The Ceylon Medical Journal. 2005; 50(Supplement 1):26 en_US
dc.identifier.issn 0009-0875 (Print)
dc.description Oral Presentation Abstract (OP41), 118th Annual Scientific Sessions, Sri Lanka Medical Association, 2005 Colombo, Sri Lanka en_US
dc.description.abstract INTRODUCTION: Although considered a mild disorder, J3 thalassemia trait has been reportedly associated with symptoms of anaemia, while in other series hepatosplenomegaly has been reported as associated with this diagnosis. No controlled study has examined the symptoms and signs of individuals with {5 thalassemia trait and compared these with age- and sex-matched normal individuals. Materials and METHODS: We administered a questionnaire to 397 parents of children with J3 thalassemia major attending the National Thalassemia Centre in Kurunagala, Sri Lanka, and to 87 normal volunteers. All individuals underwent physical examination by the same investigator, as well as testing by automated cell counter, and HPLC. RESULTS: The mean age of the parents (33 years) and controls (29.5 years) was not significantly different. In parents with thalassemia trait, 20% of males and 42% of females complained of reduced exercise tolerance compared to 12.5% of males and 38% of females in the controls. The questionnaire revealed that 41% of parents, and 36% of controls, complained of recurrent headache; 18% of parents, and 15% of controls, complained of lethargy. Mean quality-of-life score, recorded formally by a linear analog scale, from 0 to 10 was 7.1 in parents and 7.2 in controls. CONCLUSIONS: These findings suggest that, by contrast to many reports in the older literature, in uncomplicated p thalassemia trait there appears to be no symptoms or signs greater than those observed in a normal control population. en_US
dc.language.iso en_US en_US
dc.publisher Sri Lanka Medical Association en_US
dc.subject uncomplicated β thalassemia trait en_US
dc.title Reappraisal of symptoms and signs of uncomplicated β thalassemia trait en_US
dc.type Article en_US

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