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Shifting of circulating serotypes in dengue outbreaks during 2009/2010 in Sri lanka

Show simple item record Manamperi, N.H. en_US Athapaththu, A.M.M.H. en_US Premawansa, G. en_US Wellawaththage, C. en_US Jayarathna, T. D. S. S. en_US Abeyewickreme, W. en_US Hapugoda, M.D. en_US 2015-08-29T21:33:47Z en_US 2015-08-29T21:33:47Z en_US 2010 en_US
dc.identifier.citation Tropical Diseases Future Threats and New Paradigms, Proceedings of the Joint International Tropical Medicine Meeting & International Malaria Colloquium 2010 :239 en_US
dc.identifier.uri en_US
dc.description Poster Presentation Abstract (No. 70) of Joint International Tropical Medicine Meeting (JITMM 2010) & International Malaria Colloquium (IMC2010) 1-3 December 2010 Bangkok, Thailand en_US
dc.description.abstract OBJECTIVES: Sri Lanka has experienced explosive outbreaks of dengue infection in 2009 and 2010. It has been identified that DEN- 3 and DEN- 2 were the predominant serotypes with DEN-1 and DEN- 4 circulating at a lower level in previous dengue outbreaks during 2003-2006, Objective of this study was to identify the circulating serotype/s during 2009 - 2010 outbreaks. METHODOLOGY: A prospective study was carried out at North Colombo Teaching Hospital, Sri Lanka during December 2009-August 2010. Clinically suspected dengue patients, with fever less than 5 days were recruited. An interviewer administered questionnaire was filled for each patient, by a Medical Officer. Venous blood samples confirmed for the presence of dengue virus by RT-PCR were typed by Semi-Nested PCR. RESULTS: Out of the 209 patients recruited in the study 80 (38%) were positive for dengue virus by RT-PCR. Of the positives, 43 (54%) were typed and circulation of all 4 serotypes was observed- Of the 43 positives, presence of DEN-1, DEN-2, DEN-3 and DEN-4 serotypes was 34 (79%), 3 (7%), 2 (5%) and 3 (7%) respectively DEN-1 was the predominant serotype in the recent epidemics which was circulating at a low level in previous epidemics. In DEN-1 infected patients, the mean platelet value was 58,588/ rnm3 and the mean PCV value was 41.4%. Associated symptoms such as headache, retro-orbital pain, neck pain and limb pain were present in 94% (32/34), 59% (20/34), 24% (8/34J and 91% (31/34) patients respectively. Bleeding manifestation developed in 47 % (16/34) patients. The mortality rate ranged from 0.7%- 1.0% during the recent outbreaks. Acknowledgement: Financial and technical assistance from the International Centre for Genetic Engineering and Biotechnology (ICGEB CRP/ SRI08-02) and the International Atomic Energy Agency (IAEA SRI 5/042) is gratefully acknowledged. en_US
dc.language.iso en_US en_US
dc.publisher Faculty of Tropical Medicine, Mahidol University en_US
dc.subject Dengue en_US
dc.subject Dengue-epidemiology en_US
dc.title Shifting of circulating serotypes in dengue outbreaks during 2009/2010 in Sri lanka en_US
dc.type Conference Abstract en_US
dc.identifier.department Parasitology en_US
dc.identifier.department Molecular Medicine Unit en_US
dc.creator.corporateauthor Parasitology and Tropical Medicine Association of Thailand en_US
dc.creator.corporateauthor SEAMEO Regional Tropical Medicine and Public Health Network en_US
dc.creator.corporateauthor TROPMED Alumni Association en_US

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