dc.contributor.author |
Bath, P.M. |
en_US |
dc.contributor.author |
Adami, A. |
en_US |
dc.contributor.author |
Bereczki, D. |
en_US |
dc.contributor.author |
Berge, E. |
en_US |
dc.contributor.author |
Beridze, M. |
en_US |
dc.contributor.author |
Cala, L. |
en_US |
dc.contributor.author |
Casado, A. |
en_US |
dc.contributor.author |
Caso, V. |
en_US |
dc.contributor.author |
Chang, H.M. |
en_US |
dc.contributor.author |
Christensen, H. |
en_US |
dc.contributor.author |
Collins, R. |
en_US |
dc.contributor.author |
Czlonkowska, A. |
en_US |
dc.contributor.author |
Dineen, R.A. |
en_US |
dc.contributor.author |
El Etribi, A. |
en_US |
dc.contributor.author |
Ghani, A. R. |
en_US |
dc.contributor.author |
Gommans, J. |
en_US |
dc.contributor.author |
Koumellis, P. |
en_US |
dc.contributor.author |
Laska, A. C. |
en_US |
dc.contributor.author |
Lees, K. R. |
en_US |
dc.contributor.author |
Navarro, J. |
en_US |
dc.contributor.author |
Ntaios, G. |
en_US |
dc.contributor.author |
Ozturk, S. |
en_US |
dc.contributor.author |
Phillips, S. |
en_US |
dc.contributor.author |
Pocock, S. |
en_US |
dc.contributor.author |
Prasad, K. |
en_US |
dc.contributor.author |
Scutt, P. |
en_US |
dc.contributor.author |
de Silva, H.A. |
en_US |
dc.contributor.author |
Szatmari, S. |
en_US |
dc.contributor.author |
Díez-Tejedor E |
en_US |
dc.contributor.author |
Utton, S. |
en_US |
dc.contributor.author |
Wang, Y. J. |
en_US |
dc.contributor.author |
Wardlaw, J.M. |
en_US |
dc.contributor.author |
Whynes, D. |
en_US |
dc.contributor.author |
Wong, L. |
en_US |
dc.contributor.author |
Woodhouse, L |
en_US |
dc.contributor.author |
Sprigg, N. |
en_US |
dc.contributor.author |
ENOS Trial Investigators(36) |
en_US |
dc.date.accessioned |
2015-08-27T12:41:02Z |
en_US |
dc.date.available |
2015-08-27T12:41:02Z |
en_US |
dc.date.issued |
2014 |
en_US |
dc.identifier.citation |
International Journal of Stroke. 2014; 9(6): 711-20. |
en_US |
dc.identifier.issn |
1747-4930 (Print) |
en_US |
dc.identifier.issn |
1747-4949 (Electronic) |
en_US |
dc.identifier.issn |
1747-4930 (Linking) |
en_US |
dc.identifier.uri |
http://repository.kln.ac.lk/handle/123456789/9341 |
en_US |
dc.description |
Indexed in MEDLINE |
en_US |
dc.description.abstract |
BACKGROUND: High blood pressure is common in acute stroke and associated with a worse functional outcome. Many patients who present with acute stroke are taking prescribed antihypertensive therapy before their stroke. AIMS: ENOS tested whether lowering blood pressure and continuing pre-stroke antihypertensive therapy are each safe and effective. METHODS: This study is an international multi-centre prospective randomized single-blind blinded-endpoint parallel-group partial-factorial controlled trial of transdermal glyceryl trinitrate(a nitric oxide donor, given for seven-days) vs. no glyceryl trinitrate, and of continuing vs. stopping (temporarily for seven-days) pre-stroke antihypertensive drugs if relevant, in patients with acute ischaemic stroke or intracerebral haemorrhage and high systolic blood pressure (140–220 mmHg). RESULTS: Recruitment ran from July 2001 to October 2013. Four thousand eleven patients [2097 (52•3%) in the continue/stop arm] were recruited from 173 sites across 23 countries in 5 continents (Asia 14%, Continental Europe 16%, UK 64%). Baseline characteristics include: mean age 70 (standard deviation 12) years; male 57%; mean time from stroke to recruitment 26 (13) h; mean severity (Scandinavian Stroke Scale) 34(13) of 58; mean blood pressure 167 (19)/90 (13) mmHg; ischaemic stroke 83%; and intracerebral haemorrhage 16%. The main trial results will be presented in May 2014. The results will also be presented in updated Cochrane systematic reviews and included in individual patient data meta-analyses of all relevant randomized controlled trials. CONCLUSION: ENOS is a large completed international trial of blood pressure management in acute stroke and includes patients representative of many stroke services worldwide. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.publisher |
Sage Publications |
en_US |
dc.subject |
Clinical Trial |
en_US |
dc.title |
Baseline characteristics of the 4011 patients recruited into the Efficacy of Nitric Oxide in Stroke' (ENOS) trial. |
en_US |
dc.type |
Article |
en_US |
dc.identifier.department |
Pharmacology |
en_US |
dc.creator.corporateauthor |
International Stroke Society |
en_US |