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Childhood functional abdominal pain: mechanisms and management

Show simple item record Korterink, J. Devanarayana, N.M. Rajindrajith, S. Vlieger, A. Benninga, M.A. 2015-08-25T04:47:57Z 2015-08-25T04:47:57Z 2015
dc.identifier.citation Nature Reviews. Gastroenterology and Hepatology.2015;12(3):159-71 en_US
dc.identifier.issn 1759-5045 (Print)
dc.identifier.issn 1759-5053 (Electronic)
dc.description Indexed in MEDLINE en_US
dc.description.abstract Chronic abdominal pain is one of the most common clinical syndromes encountered in day to day clinical paediatric practice. Although common, its definition is confusing, predisposing factors are poorly understood and the pathophysiological mechanisms are not clear. The prevailing viewpoint in the pathogenesis involves the inter-relationship between changes in hypersensitivity and altered motility, to which several risk factors have been linked. Making a diagnosis of functional abdominal pain can be a challenge, as it is unclear which further diagnostic tests are necessary to exclude an organic cause. Moreover, large, well-performed, high-quality clinical trials for effective agents are lacking, which undermines evidence-based treatment. This Review summarizes current knowledge regarding the epidemiology, pathophysiology, risk factors and diagnostic work-up of functional abdominal pain. Finally, management options for children with functional abdominal pain are discussed including medications, dietary interventions, probiotics and psychological and complementary therapies, to improve understanding and to maximize the quality of care for children with this condition. en_US
dc.language.iso en_US en_US
dc.publisher Nature Pub. Group en_US
dc.subject Abdominal Pain en_US
dc.title Childhood functional abdominal pain: mechanisms and management en_US
dc.type Article en_US

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