Abstract:
Introduction: Malaria and tuberculosis are important diseases in Sudan.
Therefore, discovery of drugs for these diseases is very important to control
these diseases.
Methodology: Lead compounds for the treatment of many infectious and
endemic diseases such as malaria and tuberculosis were prepared. Diversed
compounds from natural and synthetic sources against drug targets related to
the causative agents of these diseases were discovered. Broad biochemical and
molecular biology techniques such as gene expression and protein
purification, enzyme inhibition and kinetics studies, lead optimization and
computational chemistry were used.
Results: Our research has resulted in a battery of promising drug leads against
many infectious and endemic diseases.
Discussion: Promising drugs are needed extensive field trials.
