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Impact of acalypha indica (Kuppamenia) phytochemicals on glucose-6-phosphate dehydrogenase deficiency: two clinical case studies

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dc.contributor.author Fernando, K.
dc.contributor.author Fernando, N.
dc.contributor.author Dayanath, B.K.T.P.
dc.contributor.author Williams, S.
dc.contributor.author Premawardhena, A.
dc.date.accessioned 2024-09-11T10:26:07Z
dc.date.available 2024-09-11T10:26:07Z
dc.date.issued 2024
dc.identifier.citation College of Chemical Pathologists of Sri Lanka, 9th Annual Academic Sessions 2024. 2024; 9: 139. en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/28396
dc.description Abstracts of E-Posters(CR 32), 9th Annual Academic Sessions, College of Chemical Pathologists of Sri lanka, 13th and 14th July 2024, Colombo, Sri Lanka. en_US
dc.description.abstract INTRODUCTION Acalypha indica, known as “kuppamenia” in Sinhala, plays a significant role in ayurvedic medicine in Sri Lanka. Despite its medicinal use, certain phytochemicals within the plant have been linked to oxidative stress-induced haemolysis in individuals deficient in glucose-6-phosphate dehydrogenase (G6PD) enzyme activity. However, we know very little regarding those chemicals due to a dearth of literature. Here, we present two cases highlighting the impact of Acalypha indica ingestion on individuals with G6PD deficiency.CASE PRESENTATION Case 1: A 65-year-old man presented with jaundice, pallor, and haematuria after consuming “Kuppamenia mallum”. His peripheral blood picture showed bite cells and Heinz bodies. Positive Brewer’s test raised the clinical suspicion of G6PD deficiency. He received blood transfusions during the acute phase and was discharged upon improvement of symptoms. Low levels of G6PD enzyme at the follow-up visit confirmed the diagnosis. Case 2: A 61-year-old male presented with respiratory distress, jaundice and haematuria, accompanied by peripheral cyanosis and hypotension. He was admitted following four days of continuous ingestion of Acalypha indica. Peripheral oxygen saturation was low, and Heinz bodies were evident in the peripheral blood film. Blotting paper methaemoglobinaemia assessment revealed a level of 70%. Despite optimal medical management, he succumbed to a cardiac arrest on the fourth day of admission.DISCUSSION AND CONCLUSIONS Despite its antioxidant properties, Acalypha indica can precipitate acute haemolysis in G6PD-deficient individuals. Symptomatology and outcomes vary with the amount ingested, underscoring the necessity for research into identifying potentially toxic phytochemicals and their concentrations. en_US
dc.language.iso en en_US
dc.publisher College of Chemical Pathologists of Sri Lanka en_US
dc.subject G6PD deficiency en_US
dc.subject Kuppamenia en_US
dc.subject Acalypha indica en_US
dc.subject Bite cells en_US
dc.subject Methaemoglobinaemia en_US
dc.title Impact of acalypha indica (Kuppamenia) phytochemicals on glucose-6-phosphate dehydrogenase deficiency: two clinical case studies en_US
dc.type Article en_US


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