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Evaluation of point-of-care testing (poct) devices for cardiac troponin i in screening patients with myocardial infarction

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dc.contributor.author Fernando, K.
dc.contributor.author Jayasekara, D.
dc.contributor.author Kulasinghe, M.
dc.contributor.author Silva, P.
dc.contributor.author Harshanee, K.G.A.T.
dc.contributor.author Bandara, S.R.R.
dc.contributor.author Dayanath, B.K.T.P.
dc.date.accessioned 2024-09-11T10:15:12Z
dc.date.available 2024-09-11T10:15:12Z
dc.date.issued 2024
dc.identifier.citation College of Chemical Pathologists of Sri Lanka, 9th Annual Academic Sessions 2024. 2024; 9: 96. en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/28382
dc.description Abstracts of E-Posters(RP 10), 9th Annual Academic Sessions, College of Chemical Pathologists of Sri lanka, 13th and 14th July 2024, Colombo, Sri Lanka. en_US
dc.description.abstract INTRODUCTION AND OBJECTIVES Cardiac troponin I (cTnI) is a crucial biomarker for diagnosing myocardial infarction (MI). However, many remote hospitals lack access to cTnI assessment facilities. This study investigates the feasibility of using Point-of Care Testing (POCT) devices to triage MI patients in such settings, facilitating their transfer to tertiary care hospitals. Assessing the quality of POCT devices is essential for this purpose. This report outlines the assessment methodology of two POCT devices and presents the obtained results.METHODS Two POCT devices, labelled X and Y, for measuring cTnI were compared against the Ortho-Vitros 3600, serving as the reference method, with optimum internal and external quality control measures. Basic specifications of the POCT devices and the comparator were obtained from their respective kit inserts. Routine patient samples were analyzed in singlicate using POCT devices and the reference method. Linear regression analysis was conducted, and correlation graphs were generated. Within-run precision was evaluated using a patient sample and imprecision (CV) was calculated for the POCT devices.RESULTS The linearity ranges for cTnI measurement with POCT devices X and Y were 0.01–15 ng/mL and 0.03–30 ng/ mL, respectively, with decision-making cutoff values for diagnosing MI established at 0.04 ng/mL and 0.5 ng/ mL, respectively. Regression analysis demonstrated acceptable linearity for both POCT devices, with correlation of R2=0.7388 for device X and R2=0.8881 for device Y. However, higher imprecision was observed for both analyzers, with a CV of 26% for device X and 20% for device Y at decision-making cutoff levels.CONCLUSIONS This study highlights major challenges associated with the implementing POCT devices for cTnI assays in triage settings aimed at diagnosing MI in acute care. Specifically, the adoption of higher cutoff levels in the POCT devices, not aligned with the recommended 99th percentile for the healthy population, and the poor precision observed at these cutoff values emerge as significant hurdles. en_US
dc.language.iso en en_US
dc.publisher College of Chemical Pathologists of Sri Lanka en_US
dc.subject Cardiac troponin en_US
dc.subject Point-of-care-devices en_US
dc.subject Myocardial infarction en_US
dc.subject Correlation en_US
dc.title Evaluation of point-of-care testing (poct) devices for cardiac troponin i in screening patients with myocardial infarction en_US
dc.type Article en_US


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