Digital Repository

Characteristics and survival of advanced untreated hepatocellular carcinoma of non-viral etiology

Show simple item record

dc.contributor.author Ekanayaka, S.P.N.
dc.contributor.author Luke, N.
dc.contributor.author Thilakarathne, S.B.
dc.contributor.author Dassanayake, A.
dc.contributor.author Gunetilleke, M.B.
dc.contributor.author Niriella, M.A.
dc.contributor.author Siriwardana, R.C.
dc.date.accessioned 2024-09-04T05:11:16Z
dc.date.available 2024-09-04T05:11:16Z
dc.date.issued 2024
dc.identifier.citation Indian Society of Gastroenterology. 2024.[Online ahead of print] en_US
dc.identifier.issn 0254-8860 (Print)
dc.identifier.issn 0975-0711 (Electronic)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/28100
dc.description Indexed in MEDLINE. en_US
dc.description.abstract INTRODUCTION AND OBJECTIVES Hepatocellular carcinoma (HCC) is an aggressive tumor and presents late. The underlying etiology of HCC is changing rapidly. HCC in Sri Lanka is unique due to its predominant non-viral etiology (nvHCC) but lacks survival data.METHOD Data was collected from patients who presented with HCC from 2011 to 2018. There were 560/568 (98.6%) nvHCC. The patients who were not candidates for tumor-specific treatment (149/560 [26.7%]) were selected. Population characteristics, demographic data, tumor characteristics, survival and factors affecting survival were analyzed.RESULTS The median age was 64 years (range 30-88) and 86% (n = 129) were males. As many as 124 (83%) were cirrhotic. The overall performance score was 80%. Nearly 21/124 tumors were detected in cirrhotic screening. Tumors were single nodular in 32 (21%), up to three nodules in 28 (18%), more than three nodules in 33 (22%) and diffusely infiltrating in 56 (37%). The major venous invasions were present in 78 (52.3%). Extra-hepatic tumor spread was seen in 19 (12.7%) (lungs 13 [72.2%], bones 2 [11.1%]). The median survival of patients receiving palliative care was three months (1-43 months). Tumor size and cirrhotic status were significant predictors in univariate analysis.CONCLUSION A quarter of nvHCCs were not amenable to treatment at presentation as they had dismal survival. en_US
dc.language.iso en en_US
dc.publisher Indian Society of Gastroenterology en_US
dc.subject Epidemiology en_US
dc.subject Hepatocellular carcinoma en_US
dc.subject Liver neoplasms en_US
dc.subject Palliative care en_US
dc.subject Survival en_US
dc.title Characteristics and survival of advanced untreated hepatocellular carcinoma of non-viral etiology en_US
dc.type Article en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Digital Repository


Browse

My Account