Digital Repository

Obesity, liver steatosis and metabolic syndrome: The hidden enemies in transfusion-dependent thalassaemia

Show simple item record

dc.contributor.author Padeniya, P.
dc.contributor.author Premawardhena, A.
dc.date.accessioned 2024-07-24T08:53:40Z
dc.date.available 2024-07-24T08:53:40Z
dc.date.issued 2024
dc.identifier.citation British Journal of Haematology.2024;205(1):28-29 en_US
dc.identifier.issn 0007-1048 (Print)
dc.identifier.issn 1365-2141 (Electronic)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/27921
dc.description Indexed in MEDLINE. en_US
dc.description.abstract In their paper, the authors quantified liver iron concentration (LIC) and hepatic steatosis (HS) using MRI-T2* technology in transfusion-dependent thalassaemia (TDT) patients and healthy controls and found that the prevalence of HS among patients with TDT was 36.4%. In comparison with healthy controls, the hepatic fat fraction (FF) was significantly higher in the TDT population (p = 0.013). Active hepatitis C virus infection, body mass index (BMI) and LIC were independent predictors of HS. An inverse correlation between hepatic FF and high-density lipoprotein cholesterol (p = 0.042) and a significant association of high glycaemia level (p = 0.037) with higher hepatic FF and a significant relationship (p = 0.026) between HS and higher BMI (though in a 'lean' group of patients) in TDT patients indicated that 'metabolic syndrome' was present in this subset with TDT. The impact of metabolic syndrome on TDT, including cardiac disease unrelated to iron overload, needs further study. Commentary on: Ricchi et al. Liver steatosis in patients with transfusion-dependent thalassaemia. Br J Haematol 2024;204:2458-2467. en_US
dc.language.iso en en_US
dc.publisher Wiley-Blackwell en_US
dc.subject NAFLD en_US
dc.subject Liver steatosis en_US
dc.subject Metabolic syndrome en_US
dc.subject Transfusion‐dependent thalassaemia en_US
dc.title Obesity, liver steatosis and metabolic syndrome: The hidden enemies in transfusion-dependent thalassaemia en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search Digital Repository


Browse

My Account